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24 mutational cancer drivers have been detected in this of Breast carcinoma (BRCA) project from Washington University. The most mutated drivers are: PIK3CA, TP53, MAP3K1, CDH1, MLL3, etc.



ER positive Breast cancer Washington University
BRCA Breast carcinoma
76 Samples
Driver / Mut. genes24 / 4009
Washington University
PMID:22722193
Coding sequence mutations (CSMs)
in driver genes 136
in all genes 4862
Protein affecting mutations (PAMs)
in driver genes 131
in all genes 2461
This driver cloud represents the most recurrently mutated cancer driver genes in the ER positive Breast cancer Washington University dataset. The size of the gene symbol is relative to the count of samples with PAMs.
This plot shows the most recurrently mutated cancer driver genes in the ER positive Breast cancer Washington University dataset. Each bar of the histogram indicates the amount of samples with PAMs.

Gene symbol Ensembl id Driver class Mutated samples % Mutated samples
PIK3CA ENSG00000121879 36 36 47.37
TP53 ENSG00000141510 14 14 18.42
MAP3K1 ENSG00000095015 8 8 10.53
CDH1 ENSG00000039068 7 7 9.21
MLL3 ENSG00000055609 5 5 6.58
RB1 ENSG00000139687 4 4 5.26
MYH9 ENSG00000100345 3 3 3.95
MLL2 ENSG00000167548 3 3 3.95
SF3B1 ENSG00000115524 3 3 3.95
CHD4 ENSG00000111642 2 2 2.63
RUNX1 ENSG00000159216 3 3 3.95
TBX3 ENSG00000135111 4 2 2.63
AHNAK ENSG00000124942 2 2 2.63
ASPM ENSG00000066279 2 2 2.63
MACF1 ENSG00000127603 3 3 3.95
EIF4A2 ENSG00000156976 3 2 2.63
SVEP1 ENSG00000165124 2 2 2.63
BRAF ENSG00000157764 2 2 2.63
CDKN1B ENSG00000111276 2 2 2.63
ERCC2 ENSG00000104884 2 2 2.63
CDK12 ENSG00000167258 2 2 2.63
PTPRU ENSG00000060656 2 2 2.63
STAG1 ENSG00000118007 2 2 2.63
CBFB ENSG00000067955 2 2 2.63