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129 mutational cancer drivers have been detected in this of Breast carcinoma (BRCA) project from The Cancer Genome Atlas. The most mutated drivers are: PIK3CA, TP53, MAP3K1, GATA3, CDH1, etc.



Breast invasive carcinoma TCGA
BRCA Breast carcinoma
762 Samples
Driver / Mut. genes129 / 19637
The Cancer Genome Atlas
doi:10.1038/nature11412
Coding sequence mutations (CSMs)
in driver genes 1672
in all genes 57792
Protein affecting mutations (PAMs)
in driver genes 1493
in all genes 29995
This driver cloud represents the most recurrently mutated cancer driver genes in the Breast invasive carcinoma TCGA dataset. The size of the gene symbol is relative to the count of samples with PAMs.
This plot shows the most recurrently mutated cancer driver genes in the Breast invasive carcinoma TCGA dataset. Each bar of the histogram indicates the amount of samples with PAMs.

Gene symbol Ensembl id Driver class Mutated samples % Mutated samples
PIK3CA ENSG00000121879 258 247 32.41
TP53 ENSG00000141510 253 251 32.94
MAP3K1 ENSG00000095015 56 54 7.09
GATA3 ENSG00000107485 82 81 10.63
CDH1 ENSG00000039068 55 53 6.96
MLL3 ENSG00000055609 50 49 6.43
NCOR1 ENSG00000141027 32 30 3.94
MAP2K4 ENSG00000065559 31 31 4.07
PTEN ENSG00000171862 30 28 3.67
RUNX1 ENSG00000159216 27 24 3.15
NF1 ENSG00000196712 21 19 2.49
CTCF ENSG00000102974 21 17 2.23
PIK3R1 ENSG00000145675 20 7 0.92
AKT1 ENSG00000142208 20 19 2.49
RB1 ENSG00000139687 17 14 1.84
TBX3 ENSG00000135111 19 17 2.23
ATM ENSG00000149311 17 16 2.10
ARID1A ENSG00000117713 17 16 2.10
ANK3 ENSG00000151150 15 15 1.97
CBFB ENSG00000067955 17 15 1.97
BRCA2 ENSG00000139618 14 12 1.57
MED23 ENSG00000112282 14 12 1.57
BRCA1 ENSG00000012048 14 11 1.44
SF3B1 ENSG00000115524 14 14 1.84
RPGR ENSG00000156313 13 11 1.44
MLLT4 ENSG00000130396 12 8 1.05
FOXA1 ENSG00000129514 13 13 1.71
STAG2 ENSG00000101972 13 7 0.92
PRKAR1A ENSG00000108946 12 4 0.52
HCFC1 ENSG00000172534 12 11 1.44
MYH14 ENSG00000105357 12 11 1.44
MYB ENSG00000118513 11 10 1.31
ZFP36L1 ENSG00000185650 10 8 1.05
TBL1XR1 ENSG00000177565 8 7 0.92
CASP8 ENSG00000064012 10 10 1.31
CAD ENSG00000084774 9 8 1.05
ARID4B ENSG00000054267 9 7 0.92
CCAR1 ENSG00000060339 9 9 1.18
SRGAP1 ENSG00000196935 8 8 1.05
ACVR1B ENSG00000135503 7 6 0.79
CDKN1B ENSG00000111276 7 7 0.92
RFC4 ENSG00000163918 6 2 0.26
KRAS ENSG00000133703 7 5 0.66
GPS2 ENSG00000132522 6 6 0.79
NSD1 ENSG00000165671 7 2 0.26
MED24 ENSG00000008838 5 3 0.39
POLR2B ENSG00000047315 6 2 0.26
FLT3 ENSG00000122025 6 3 0.39
BPTF ENSG00000171634 6 3 0.39
BMPR2 ENSG00000204217 5 3 0.39
PBRM1 ENSG00000163939 5 3 0.39
MLH1 ENSG00000076242 4 2 0.26
CIC ENSG00000079432 5 2 0.26
LRP6 ENSG00000070018 5 3 0.39
CNOT3 ENSG00000088038 5 3 0.39
AFF4 ENSG00000072364 5 3 0.39
TOM1 ENSG00000100284 4 3 0.39
TCF7L2 ENSG00000148737 4 3 0.39
CAST ENSG00000153113 4 3 0.39
MUC20 ENSG00000176945 4 2 0.26
ERBB2IP ENSG00000112851 4 3 0.39
HSPA8 ENSG00000109971 4 2 0.26
NUP107 ENSG00000111581 4 3 0.39
DDX3X ENSG00000215301 4 2 0.26
ITSN1 ENSG00000205726 4 3 0.39
CHEK2 ENSG00000183765 4 3 0.39
SOS1 ENSG00000115904 4 3 0.39
DDX5 ENSG00000108654 4 3 0.39
DIS3 ENSG00000083520 4 3 0.39
MKL1 ENSG00000196588 4 2 0.26
ARFGEF2 ENSG00000124198 4 3 0.39
PIP5K1A ENSG00000143398 4 2 0.26
NOTCH1 ENSG00000148400 3 3 0.39
HLF ENSG00000108924 4 3 0.39
RBM5 ENSG00000003756 3 3 0.39
MAX ENSG00000125952 3 2 0.26
RBBP7 ENSG00000102054 3 2 0.26
STIP1 ENSG00000168439 3 2 0.26
BAP1 ENSG00000163930 3 2 0.26
SMAD4 ENSG00000141646 3 3 0.39
ELF1 ENSG00000120690 3 2 0.26
CLTC ENSG00000141367 3 2 0.26
BRAF ENSG00000157764 3 3 0.39
RPL5 ENSG00000122406 3 3 0.39
ATIC ENSG00000138363 3 3 0.39
LCP1 ENSG00000136167 3 3 0.39
IDH1 ENSG00000138413 3 2 0.26
STK4 ENSG00000101109 3 3 0.39
TGFBR2 ENSG00000163513 3 3 0.39
CLASP2 ENSG00000163539 3 3 0.39
NF2 ENSG00000186575 3 2 0.26
CSDE1 ENSG00000009307 3 2 0.26
ZFP36L2 ENSG00000152518 3 2 0.26
ACO1 ENSG00000122729 3 2 0.26
EIF2C3 ENSG00000126070 3 2 0.26
THRAP3 ENSG00000054118 3 3 0.39
TNPO1 ENSG00000083312 3 3 0.39
EIF4G1 ENSG00000114867 3 2 0.26
PHF6 ENSG00000156531 3 3 0.39
FUBP1 ENSG00000162613 3 2 0.26
PCSK6 ENSG00000140479 3 3 0.39
SEC24D ENSG00000150961 3 3 0.39
ARNTL ENSG00000133794 3 2 0.26
NDRG1 ENSG00000104419 2 2 0.26
HNRPDL ENSG00000152795 2 2 0.26
HLA-A ENSG00000206503 2 2 0.26
CUL1 ENSG00000055130 2 2 0.26
EIF1AX ENSG00000173674 2 2 0.26
TFDP1 ENSG00000198176 2 2 0.26
GOLGA5 ENSG00000066455 2 2 0.26
ACTB ENSG00000075624 2 2 0.26
PAX5 ENSG00000196092 2 2 0.26
KLF4 ENSG00000136826 2 2 0.26
CARM1 ENSG00000142453 2 2 0.26
MSR1 ENSG00000038945 2 2 0.26
SOS2 ENSG00000100485 2 2 0.26
G3BP2 ENSG00000138757 2 2 0.26
DHX15 ENSG00000109606 2 2 0.26
SFPQ ENSG00000116560 2 2 0.26
CLSPN ENSG00000092853 2 2 0.26
AQR ENSG00000021776 2 2 0.26
PIK3R3 ENSG00000117461 2 2 0.26
CSNK1G3 ENSG00000151292 2 2 0.26
FUS ENSG00000089280 2 2 0.26
ATF1 ENSG00000123268 2 2 0.26
STK11 ENSG00000118046 2 2 0.26
ACSL6 ENSG00000164398 2 2 0.26
PTGS1 ENSG00000095303 2 2 0.26
TCF12 ENSG00000140262 2 2 0.26