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42 mutational cancer drivers have been detected in this of Breast carcinoma (BRCA) project from Sanger Institute. The most mutated drivers are: TP53, PIK3CA, GATA3, MLL3, MAP3K1, etc.



Breast Cancer Sanger Institute
BRCA Breast carcinoma
100 Samples
Driver / Mut. genes42 / 7350
Sanger Institute
PMID:22722201
Coding sequence mutations (CSMs)
in driver genes 225
in all genes 10513
Protein affecting mutations (PAMs)
in driver genes 212
in all genes 5617
This driver cloud represents the most recurrently mutated cancer driver genes in the Breast Cancer Sanger Institute dataset. The size of the gene symbol is relative to the count of samples with PAMs.
This plot shows the most recurrently mutated cancer driver genes in the Breast Cancer Sanger Institute dataset. Each bar of the histogram indicates the amount of samples with PAMs.

Gene symbol Ensembl id Driver class Mutated samples % Mutated samples
TP53 ENSG00000141510 37 36 36.00
PIK3CA ENSG00000121879 31 30 30.00
GATA3 ENSG00000107485 15 15 15.00
MLL3 ENSG00000055609 11 11 11.00
MAP3K1 ENSG00000095015 6 6 6.00
CDH1 ENSG00000039068 8 8 8.00
AKT1 ENSG00000142208 5 5 5.00
ARID1A ENSG00000117713 4 4 4.00
SF3B1 ENSG00000115524 4 4 4.00
CASP8 ENSG00000064012 3 3 3.00
NF1 ENSG00000196712 5 3 3.00
ATM ENSG00000149311 4 3 3.00
TRIO ENSG00000038382 4 3 3.00
PTEN ENSG00000171862 3 3 3.00
RB1 ENSG00000139687 3 2 2.00
SETD2 ENSG00000181555 2 2 2.00
APC ENSG00000134982 3 3 3.00
FBXW7 ENSG00000109670 3 3 3.00
CSDE1 ENSG00000009307 3 3 3.00
MLL2 ENSG00000167548 3 2 2.00
SPTAN1 ENSG00000197694 3 3 3.00
ARFGEF2 ENSG00000124198 3 2 2.00
SETDB1 ENSG00000143379 3 2 2.00
MACF1 ENSG00000127603 3 3 3.00
ARID2 ENSG00000189079 3 3 3.00
NUP98 ENSG00000110713 3 3 3.00
TOM1 ENSG00000100284 2 2 2.00
MECOM ENSG00000085276 2 2 2.00
BAP1 ENSG00000163930 2 2 2.00
SMAD4 ENSG00000141646 2 2 2.00
CEP290 ENSG00000198707 2 2 2.00
PIK3CB ENSG00000051382 2 2 2.00
CCT5 ENSG00000150753 2 2 2.00
DDX5 ENSG00000108654 2 2 2.00
ATR ENSG00000175054 2 2 2.00
ARHGAP35 ENSG00000160007 2 2 2.00
DHX15 ENSG00000109606 2 2 2.00
SUZ12 ENSG00000178691 2 2 2.00
CCAR1 ENSG00000060339 2 2 2.00
EP300 ENSG00000100393 2 2 2.00
NR4A2 ENSG00000153234 2 2 2.00
FMR1 ENSG00000102081 2 2 2.00