Top

11 mutational cancer drivers have been detected in this of Breast carcinoma (BRCA) project from Johns Hopkins University. The most mutated drivers are: TP53, SPTAN1, CIC, BRCA1, TAF1, etc.



Breast Cancer Johns Hopkins University
BRCA Breast carcinoma
42 Samples
Driver / Mut. genes11 / 1008
Johns Hopkins University
PMID:17932254
Coding sequence mutations (CSMs)
in driver genes 43
in all genes 1332
Protein affecting mutations (PAMs)
in driver genes 42
in all genes 909
This driver cloud represents the most recurrently mutated cancer driver genes in the Breast Cancer Johns Hopkins University dataset. The size of the gene symbol is relative to the count of samples with PAMs.
This plot shows the most recurrently mutated cancer driver genes in the Breast Cancer Johns Hopkins University dataset. Each bar of the histogram indicates the amount of samples with PAMs.

Gene symbol Ensembl id Driver class Mutated samples % Mutated samples
TP53 ENSG00000141510 18 17 40.48
SPTAN1 ENSG00000197694 5 5 11.90
CIC ENSG00000079432 3 3 7.14
BRCA1 ENSG00000012048 3 3 7.14
TAF1 ENSG00000147133 2 2 4.76
FN1 ENSG00000115414 2 2 4.76
KEAP1 ENSG00000079999 2 2 4.76
G3BP2 ENSG00000138757 2 2 4.76
ARFGEF2 ENSG00000124198 2 2 4.76
AKAP9 ENSG00000127914 2 2 4.76
NUP98 ENSG00000110713 2 2 4.76