IntOGen - HRAS gene cancer mutations in BRCA

HRAS is detected as a mutational cancer driver in Invasive Breast Carcinoma

HRAS reports in Invasive Breast Carcinoma (BRCA)

Methods
Mutation distribution

Cancer type details

Invasive Breast Carcinoma
Cohorts 14 Samples 3,201 Mutations 19,887,724 Driver genes 117

Gene details

HRAS
Ensembl ID ENSG00000174775 Transcript ID ENST00000451590 Protein ID ENSP00000407586
Cohorts where is driver 1 Mutated samples 5 Mutated samples (%) 0.16 Mutations 12
Mode of action Activating
Known driver True

Method signals per Cohort

Cohort	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Highlight in X-axis:

Mutation (GRCh38)	Protein Position	Samples	Samples (%)	Consequence