IntOGen - ZFHX3 gene cancer mutations

ZFHX3 is detected as a mutational cancer driver

ZFHX3 reports

Methods
Mutation distribution

Gene details

ZFHX3
Ensembl ID ENSG00000140836 Transcript ID ENST00000641206 Protein ID ENSP00000493252
Cancer types where is driver 12 Cohorts where is driver 21 Mutated samples 240 Mutations 1,485
Mode of action Ambiguous
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence