IntOGen - TBX3 gene cancer mutations

TBX3 is detected as a mutational cancer driver

TBX3 reports

Methods
Mutation distribution

Gene details

TBX3
Ensembl ID ENSG00000135111 Transcript ID ENST00000257566 Protein ID ENSP00000257566
Cancer types where is driver 4 Cohorts where is driver 8 Mutated samples 85 Mutations 328
Mode of action Loss of function
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence