IntOGen - SMO gene cancer mutations

SMO is detected as a mutational cancer driver

SMO reports

Methods
Mutation distribution

Gene details

SMO
Ensembl ID ENSG00000128602 Transcript ID ENST00000249373 Protein ID ENSP00000249373
Cancer types where is driver 5 Cohorts where is driver 9 Mutated samples 50 Mutations 228
Mode of action Activating
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence