IntOGen - SMC1A gene cancer mutations

SMC1A is detected as a mutational cancer driver

SMC1A reports

Methods
Mutation distribution

Gene details

SMC1A
Ensembl ID ENSG00000072501 Transcript ID ENST00000322213 Protein ID ENSP00000323421
Cancer types where is driver 1 Cohorts where is driver 2 Mutated samples 9 Mutations 278
Mode of action Activating
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence