IntOGen - SMARCA4 gene cancer mutations

SMARCA4 is detected as a mutational cancer driver

SMARCA4 reports

Methods
Mutation distribution

Gene details

SMARCA4
Ensembl ID ENSG00000127616 Transcript ID ENST00000344626 Protein ID ENSP00000343896
Cancer types where is driver 15 Cohorts where is driver 25 Mutated samples 253 Mutations 748
Mode of action Loss of function
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence