SMAD4 is detected as a mutational cancer driver
SMAD4 reports
Gene details
SMAD4 |
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Ensembl ID
ENSG00000141646
Transcript ID ENST00000342988 Protein ID ENSP00000341551 |
Cancer types where is driver
9
Cohorts where is driver 29 Mutated samples 466 Mutations 598 |
Mode of action Loss of function |
Known driver True |
Method signals per Cancer Type
Cancer type | Methods | Samples | Samples (%) |
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In-silico saturation mutagenesis
Model | Mutations | Driver mutations | Driver mutations (%) |
---|---|---|---|
COREAD (Colorectal adenocarcinoma) | 101 | 90 | 89.11 |
ESCA (Esophageal cancer) | 57 | 50 | 87.72 |
PA (Pancreatic cancer) | 2 | 2 | 100.00 |
PAAD (Pancreas adenocarcinoma) | 119 | 105 | 88.24 |
Observed mutations in tumors
Mutation (GRCh38) | Protein Position | Samples | Consequence |
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