IntOGen - RHOA gene cancer mutations

RHOA is detected as a mutational cancer driver

RHOA reports

Methods
Mutation distribution

Gene details

RHOA
Ensembl ID ENSG00000067560 Transcript ID ENST00000418115 Protein ID ENSP00000400175
Cancer types where is driver 8 Cohorts where is driver 10 Mutated samples 77 Mutations 184
Mode of action Activating
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence