IntOGen - PTPN11 gene cancer mutations

PTPN11 is detected as a mutational cancer driver

PTPN11 reports

Methods
Mutation distribution

Gene details

PTPN11
Ensembl ID ENSG00000179295 Transcript ID ENST00000635625 Protein ID ENSP00000489597
Cancer types where is driver 9 Cohorts where is driver 14 Mutated samples 101 Mutations 261
Mode of action Activating
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence