PTEN is detected as a mutational cancer driver
PTEN reports
Gene details
PTEN |
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Ensembl ID
ENSG00000171862
Transcript ID ENST00000371953 Protein ID ENSP00000361021 |
Cancer types where is driver
28
Cohorts where is driver 61 Mutated samples 904 Mutations 1,143 |
Mode of action Loss of function |
Known driver True |
Method signals per Cancer Type
Cancer type | Methods | Samples | Samples (%) |
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In-silico saturation mutagenesis
Model | Mutations | Driver mutations | Driver mutations (%) |
---|---|---|---|
BRCA (Breast adenocarcinoma) | 85 | 71 | 83.53 |
CNS (Central nervous system cancer) | 6 | 6 | 100.00 |
G (Glioma) | 31 | 24 | 77.42 |
GBM (Glioblastoma) | 98 | 80 | 81.63 |
PRAD (Prostate adenocarcinoma) | 70 | 62 | 88.57 |
UCEC (Endometrial cancer) | 151 | 120 | 79.47 |
Observed mutations in tumors
Mutation (GRCh38) | Protein Position | Samples | Consequence |
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