IntOGen - PTCH1 gene cancer mutations

PTCH1 is detected as a mutational cancer driver

PTCH1 reports

Methods
Mutation distribution

Gene details

PTCH1
Ensembl ID ENSG00000185920 Transcript ID ENST00000331920 Protein ID ENSP00000332353
Cancer types where is driver 8 Cohorts where is driver 14 Mutated samples 132 Mutations 771
Mode of action Ambiguous
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence