PIK3CA is detected as a mutational cancer driver
PIK3CA reports
Gene details
PIK3CA |
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Ensembl ID
ENSG00000121879
Transcript ID ENST00000263967 Protein ID ENSP00000263967 |
Cancer types where is driver
36
Cohorts where is driver 87 Mutated samples 2,157 Mutations 2,453 |
Mode of action Activating |
Known driver True |
Method signals per Cancer Type
Cancer type | Methods | Samples | Samples (%) |
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In-silico saturation mutagenesis
Model | Mutations | Driver mutations | Driver mutations (%) |
---|---|---|---|
BLCA (Bladder cancer) | 87 | 60 | 68.97 |
BRCA (Breast adenocarcinoma) | 190 | 131 | 68.95 |
CESC (Cervix squamous cancer) | 29 | 24 | 82.76 |
CNS (Central nervous system cancer) | 15 | 14 | 93.33 |
COREAD (Colorectal adenocarcinoma) | 106 | 81 | 76.42 |
ESCA (Esophageal cancer) | 39 | 28 | 71.79 |
G (Glioma) | 78 | 63 | 80.77 |
HNSC (Head and neck squamous cell carcinoma) | 45 | 31 | 68.89 |
LUNG_CANCER (Lung cancer) | 6 | 4 | 66.67 |
NSCLC (Non-small cell lung cancer) | 82 | 59 | 71.95 |
ST (Stomach adenocarcinoma) | 45 | 35 | 77.78 |
UCEC (Endometrial cancer) | 101 | 76 | 75.25 |
Observed mutations in tumors
Mutation (GRCh38) | Protein Position | Samples | Consequence |
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