IntOGen - NOTCH2 gene cancer mutations

NOTCH2 is detected as a mutational cancer driver

NOTCH2 reports

Methods
Mutation distribution

Gene details

NOTCH2
Ensembl ID ENSG00000134250 Transcript ID ENST00000256646 Protein ID ENSP00000256646
Cancer types where is driver 15 Cohorts where is driver 21 Mutated samples 171 Mutations 957
Mode of action Ambiguous
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence