IntOGen - NOTCH1 gene cancer mutations

NOTCH1 is detected as a mutational cancer driver

NOTCH1 reports

Methods
Mutation distribution

Gene details

NOTCH1
Ensembl ID ENSG00000148400 Transcript ID ENST00000277541 Protein ID ENSP00000277541
Cancer types where is driver 18 Cohorts where is driver 27 Mutated samples 420 Mutations 813
Mode of action Ambiguous
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence