NFE2L2 is detected as a mutational cancer driver
NFE2L2 reports
Gene details
NFE2L2 |
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Ensembl ID
ENSG00000116044
Transcript ID ENST00000397062 Protein ID ENSP00000380252 |
Cancer types where is driver
8
Cohorts where is driver 15 Mutated samples 264 Mutations 408 |
Mode of action Activating |
Known driver True |
Method signals per Cancer Type
Cancer type | Methods | Samples | Samples (%) |
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In-silico saturation mutagenesis
Model | Mutations | Driver mutations | Driver mutations (%) |
---|---|---|---|
HC (Hepatic cancer) | 62 | 51 | 82.26 |
LIVER () | 1 | 1 | 100.00 |
LUSC (Lung squamous cell carcinoma) | 50 | 39 | 78.00 |
NSCLC (Non-small cell lung cancer) | 30 | 15 | 50.00 |
Observed mutations in tumors
Mutation (GRCh38) | Protein Position | Samples | Consequence |
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