IntOGen - NF2 gene cancer mutations

NF2 is detected as a mutational cancer driver

NF2 reports

Methods
Mutation distribution

Gene details

NF2
Ensembl ID ENSG00000186575 Transcript ID ENST00000338641 Protein ID ENSP00000344666
Cancer types where is driver 9 Cohorts where is driver 11 Mutated samples 54 Mutations 201
Mode of action Loss of function
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence