IntOGen - MEN1 gene cancer mutations

MEN1 is detected as a mutational cancer driver

MEN1 reports

Methods
Mutation distribution

Gene details

MEN1
Ensembl ID ENSG00000133895 Transcript ID ENST00000337652 Protein ID ENSP00000337088
Cancer types where is driver 5 Cohorts where is driver 6 Mutated samples 40 Mutations 208
Mode of action Loss of function
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence