IntOGen - MED12 gene cancer mutations

MED12 is detected as a mutational cancer driver

MED12 reports

Methods
Mutation distribution

Gene details

MED12
Ensembl ID ENSG00000184634 Transcript ID ENST00000374080 Protein ID ENSP00000363193
Cancer types where is driver 7 Cohorts where is driver 11 Mutated samples 74 Mutations 663
Mode of action Activating
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence