IntOGen - MAP3K1 gene cancer mutations

MAP3K1 is detected as a mutational cancer driver

MAP3K1 reports

Methods
Mutation distribution

Gene details

MAP3K1
Ensembl ID ENSG00000095015 Transcript ID ENST00000399503 Protein ID ENSP00000382423
Cancer types where is driver 7 Cohorts where is driver 12 Mutated samples 193 Mutations 410
Mode of action Loss of function
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence