IntOGen - KDR gene cancer mutations

KDR is detected as a mutational cancer driver

KDR reports

Methods
Mutation distribution

Gene details

KDR
Ensembl ID ENSG00000128052 Transcript ID ENST00000645273 Protein ID ENSP00000495159
Cancer types where is driver 7 Cohorts where is driver 8 Mutated samples 60 Mutations 677
Mode of action Activating
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence