IntOGen - HLA-B gene cancer mutations

HLA-B is detected as a mutational cancer driver

HLA-B reports

Methods
Mutation distribution

Gene details

HLA-B
Ensembl ID ENSG00000234745 Transcript ID ENST00000412585 Protein ID ENSP00000399168
Cancer types where is driver 5 Cohorts where is driver 6 Mutated samples 45 Mutations 347
Mode of action Ambiguous
Known driver False

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence