IntOGen - HLA-A gene cancer mutations

HLA-A is detected as a mutational cancer driver

HLA-A reports

Methods
Mutation distribution

Gene details

HLA-A
Ensembl ID ENSG00000206503 Transcript ID ENST00000396634 Protein ID ENSP00000379873
Cancer types where is driver 9 Cohorts where is driver 13 Mutated samples 100 Mutations 333
Mode of action Ambiguous
Known driver False

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence