IntOGen - GNAS gene cancer mutations

GNAS is detected as a mutational cancer driver

GNAS reports

Methods
Mutation distribution

Gene details

GNAS
Ensembl ID ENSG00000087460 Transcript ID ENST00000371100 Protein ID ENSP00000360141
Cancer types where is driver 9 Cohorts where is driver 14 Mutated samples 76 Mutations 570
Mode of action Activating
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence