IntOGen - FOXA2 gene cancer mutations

FOXA2 is detected as a mutational cancer driver

FOXA2 reports

Methods
Mutation distribution

Gene details

FOXA2
Ensembl ID ENSG00000125798 Transcript ID ENST00000419308 Protein ID ENSP00000400341
Cancer types where is driver 1 Cohorts where is driver 2 Mutated samples 25 Mutations 189
Mode of action Loss of function
Known driver False

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence