IntOGen - FAT2 gene cancer mutations

FAT2 is detected as a mutational cancer driver

FAT2 reports

Methods
Mutation distribution

Gene details

FAT2
Ensembl ID ENSG00000086570 Transcript ID ENST00000261800 Protein ID ENSP00000261800
Cancer types where is driver 1 Cohorts where is driver 1 Mutated samples 4 Mutations 1,729
Mode of action Loss of function
Known driver False

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence