IntOGen - ERBB2 gene cancer mutations

ERBB2 is detected as a mutational cancer driver

ERBB2 reports

Methods
Mutation distribution

Gene details

ERBB2
Ensembl ID ENSG00000141736 Transcript ID ENST00000269571 Protein ID ENSP00000269571
Cancer types where is driver 10 Cohorts where is driver 20 Mutated samples 270 Mutations 532
Mode of action Activating
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence