IntOGen - EPHA2 gene cancer mutations

EPHA2 is detected as a mutational cancer driver

EPHA2 reports

Methods
Mutation distribution

Gene details

EPHA2
Ensembl ID ENSG00000142627 Transcript ID ENST00000358432 Protein ID ENSP00000351209
Cancer types where is driver 1 Cohorts where is driver 2 Mutated samples 11 Mutations 495
Mode of action Loss of function
Known driver False

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence