IntOGen - EP300 gene cancer mutations

EP300 is detected as a mutational cancer driver

EP300 reports

Methods
Mutation distribution

Gene details

EP300
Ensembl ID ENSG00000100393 Transcript ID ENST00000263253 Protein ID ENSP00000263253
Cancer types where is driver 12 Cohorts where is driver 20 Mutated samples 225 Mutations 665
Mode of action Loss of function
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence