IntOGen - CUL3 gene cancer mutations

CUL3 is detected as a mutational cancer driver

CUL3 reports

Methods
Mutation distribution

Gene details

CUL3
Ensembl ID ENSG00000036257 Transcript ID ENST00000264414 Protein ID ENSP00000264414
Cancer types where is driver 3 Cohorts where is driver 4 Mutated samples 32 Mutations 349
Mode of action Ambiguous
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence