IntOGen - CTCF gene cancer mutations

CTCF is detected as a mutational cancer driver

CTCF reports

Methods
Mutation distribution

Gene details

CTCF
Ensembl ID ENSG00000102974 Transcript ID ENST00000646076 Protein ID ENSP00000494538
Cancer types where is driver 6 Cohorts where is driver 9 Mutated samples 115 Mutations 285
Mode of action Loss of function
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence