IntOGen - CDKN1B gene cancer mutations

CDKN1B is detected as a mutational cancer driver

CDKN1B reports

Methods
Mutation distribution

Gene details

CDKN1B
Ensembl ID ENSG00000111276 Transcript ID ENST00000228872 Protein ID ENSP00000228872
Cancer types where is driver 6 Cohorts where is driver 10 Mutated samples 49 Mutations 152
Mode of action Loss of function
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence