IntOGen - BRCA1 gene cancer mutations

BRCA1 is detected as a mutational cancer driver

BRCA1 reports

Methods
Mutation distribution

Gene details

BRCA1
Ensembl ID ENSG00000012048 Transcript ID ENST00000471181 Protein ID ENSP00000418960
Cancer types where is driver 4 Cohorts where is driver 9 Mutated samples 88 Mutations 624
Mode of action Ambiguous
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence