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Note: You're navigating the results of models obtained with the previous release of IntOGen (2020). A new boostDM version corresponding to the current IntOGen release will be available soon.
NSD1 HNSC ×
Select a mutation to see further information
Mutation AA change Consequence type BoostDM score IntOGen frequency
5:177282522:T R1984* stop_gained 1.00 2
5:177210761:T R788* stop_gained 0.99 2
5:177269800:A Y1834* stop_gained 0.99 2
5:177238486:T E1391* stop_gained 1.00 1
5:177211878:A W1160* stop_gained 1.00 1
5:177251811:T E1575* stop_gained 1.00 1
5:177248184:T E1501* stop_gained 1.00 1
5:177248229:T E1516* stop_gained 1.00 1
5:177248283:T E1534* stop_gained 1.00 1
5:177273719:T E1853* stop_gained 1.00 1
5:177283872:A W2032* stop_gained 1.00 1
5:177280724:T G1928* stop_gained 1.00 1
5:177282507:T E1979* stop_gained 1.00 1
5:177239860:T K1433* stop_gained 1.00 1
5:177211367:T E990* stop_gained 1.00 1
5:177210200:T K601* stop_gained 1.00 1
5:177210434:T Q679* stop_gained 1.00 1
5:177260120:T R1700* stop_gained 1.00 1
5:177210519:G S707* stop_gained 1.00 1
5:177211274:T G959* stop_gained 0.99 1
5:177210630:G S744* stop_gained 0.99 1
5:177238391:A S1359* stop_gained 0.99 1
5:177210775:A C792* stop_gained 0.99 1
5:177246716:T R1473* stop_gained 0.99 1
5:177211613:T R1072* stop_gained 0.99 1
5:177260152:A C1710* stop_gained 0.99 1
5:177238333:T E1340* stop_gained 1.00 0
5:177238453:T E1380* stop_gained 1.00 0
5:177204236:T E394* stop_gained 1.00 0
5:177238351:T E1346* stop_gained 1.00 0
5:177238372:T E1353* stop_gained 1.00 0
5:177238483:T E1390* stop_gained 1.00 0
5:177238414:T E1367* stop_gained 1.00 0
5:177251743:A L1552* stop_gained 1.00 0
5:177267660:T K1749* stop_gained 1.00 0
5:177248232:T E1517* stop_gained 1.00 0
5:177135404:T E101* stop_gained 1.00 0
5:177235830:G S1269* stop_gained 1.00 0
5:177235830:A S1269* stop_gained 1.00 0
5:177257037:T E1618* stop_gained 1.00 0
5:177260165:T E1715* stop_gained 1.00 0
5:177135356:T E85* stop_gained 1.00 0
5:177210990:A L864* stop_gained 1.00 0
5:177295388:T E2674* stop_gained 1.00 0
5:177210981:A L861* stop_gained 1.00 0
5:177210981:G L861* stop_gained 1.00 0
5:177295229:T E2621* stop_gained 1.00 0
5:177295242:A W2625* stop_gained 1.00 0
5:177210290:T K631* stop_gained 1.00 0
5:177251802:T G1572* stop_gained 1.00 0
5:177210356:T E653* stop_gained 1.00 0
5:177211787:T E1130* stop_gained 1.00 0
5:177211879:A W1160* stop_gained 1.00 0
5:177246779:T E1494* stop_gained 1.00 0
5:177235869:A L1282* stop_gained 1.00 0
5:177210332:T G645* stop_gained 1.00 0
5:177211037:T G880* stop_gained 1.00 0
5:177211295:T E966* stop_gained 1.00 0
5:177210776:T K793* stop_gained 1.00 0
5:177211103:T E902* stop_gained 1.00 0
5:177280736:T Q1932* stop_gained 1.00 0
5:177211169:T E924* stop_gained 1.00 0
5:177209873:T K492* stop_gained 1.00 0
5:177292146:T K2151* stop_gained 1.00 0
5:177239770:T K1403* stop_gained 1.00 0
5:177239782:T K1407* stop_gained 1.00 0
5:177239791:T K1410* stop_gained 1.00 0
5:177239794:T K1411* stop_gained 1.00 0
5:177239836:T K1425* stop_gained 1.00 0
5:177239839:T K1426* stop_gained 1.00 0
5:177251853:T G1589* stop_gained 1.00 0
5:177209933:T K512* stop_gained 1.00 0
5:177209918:T K507* stop_gained 1.00 0
5:177209900:T K501* stop_gained 1.00 0
5:177210689:T E764* stop_gained 1.00 0
5:177292080:T Q2129* stop_gained 1.00 0
5:177238258:T E1315* stop_gained 1.00 0
5:177238252:T E1313* stop_gained 1.00 0
5:177273705:A L1848* stop_gained 1.00 0
5:177273705:G L1848* stop_gained 1.00 0
5:177210971:T K858* stop_gained 1.00 0
5:177210932:T K845* stop_gained 1.00 0
5:177211046:T K883* stop_gained 1.00 0
5:177211128:A L910* stop_gained 1.00 0
5:177211140:A L914* stop_gained 1.00 0
5:177192010:T K352* stop_gained 1.00 0
5:177191899:T K315* stop_gained 1.00 0
5:177191950:T K332* stop_gained 1.00 0
5:177191944:T K330* stop_gained 1.00 0
5:177191914:T K320* stop_gained 1.00 0
5:177267633:T E1740* stop_gained 1.00 0
5:177192016:T K354* stop_gained 1.00 0
5:177191893:T K313* stop_gained 1.00 0
5:177191896:T K314* stop_gained 1.00 0
5:177204275:T K407* stop_gained 1.00 0
5:177210140:T E581* stop_gained 1.00 0
5:177210785:T E796* stop_gained 1.00 0
5:177282468:T E1966* stop_gained 1.00 0
5:177239803:T E1414* stop_gained 1.00 0
5:177204269:T K405* stop_gained 1.00 0
5:177209661:A W421* stop_gained 1.00 0
5:177204197:T K381* stop_gained 1.00 0
5:177209662:A W421* stop_gained 1.00 0
5:177210047:T E550* stop_gained 1.00 0
5:177235931:T E1303* stop_gained 1.00 0
5:177209954:T E519* stop_gained 1.00 0
5:177209864:T E489* stop_gained 1.00 0
5:177248295:T G1538* stop_gained 1.00 0
5:177293876:T E2170* stop_gained 1.00 0
5:177212012:T E1205* stop_gained 1.00 0
5:177248241:T E1520* stop_gained 1.00 0
5:177210992:T K865* stop_gained 1.00 0
5:177251826:T K1580* stop_gained 1.00 0
5:177251739:T K1551* stop_gained 1.00 0
5:177235922:T K1300* stop_gained 1.00 0
5:177235919:T K1299* stop_gained 1.00 0
5:177235913:T K1297* stop_gained 1.00 0
5:177235910:T K1296* stop_gained 1.00 0
5:177235907:T K1295* stop_gained 1.00 0
5:177235859:T K1279* stop_gained 1.00 0
5:177257034:T E1617* stop_gained 1.00 0
5:177235838:T K1272* stop_gained 1.00 0
5:177235850:T K1276* stop_gained 1.00 0
5:177191926:T G324* stop_gained 1.00 0
5:177210929:T E844* stop_gained 1.00 0
5:177210956:T E853* stop_gained 1.00 0
5:177248322:T Q1547* stop_gained 1.00 0
5:177191967:A W337* stop_gained 1.00 0
5:177191966:A W337* stop_gained 1.00 0
5:177191964:A W336* stop_gained 1.00 0
5:177191963:A W336* stop_gained 1.00 0
5:177191940:A W328* stop_gained 1.00 0
5:177191939:A W328* stop_gained 1.00 0
5:177280817:T K1959* stop_gained 1.00 0
5:177204266:T Q404* stop_gained 1.00 0
5:177294080:T E2238* stop_gained 1.00 0
5:177273707:T K1849* stop_gained 1.00 0
5:177291984:T K2097* stop_gained 1.00 0
5:177293834:T K2156* stop_gained 1.00 0
5:177269804:T K1836* stop_gained 1.00 0
5:177204194:T G380* stop_gained 1.00 0
5:177280829:T K1963* stop_gained 1.00 0
5:177210995:T E866* stop_gained 1.00 0
5:177210986:T E863* stop_gained 1.00 0
5:177291993:T K2100* stop_gained 1.00 0
5:177248220:T E1513* stop_gained 1.00 0
5:177280634:T K1898* stop_gained 1.00 0
5:177256974:T K1597* stop_gained 1.00 0
5:177211166:T K923* stop_gained 1.00 0
5:177269765:T K1823* stop_gained 1.00 0
5:177292095:T K2134* stop_gained 1.00 0
5:177292038:T K2115* stop_gained 1.00 0
5:177251806:A L1573* stop_gained 1.00 0
5:177293951:T K2195* stop_gained 1.00 0
5:177251758:A L1557* stop_gained 1.00 0
5:177251758:G L1557* stop_gained 1.00 0
5:177211115:T K906* stop_gained 1.00 0
5:177251769:T Q1561* stop_gained 1.00 0
5:177288878:T K2071* stop_gained 1.00 0
5:177235832:T E1270* stop_gained 1.00 0
5:177235880:T E1286* stop_gained 1.00 0
5:177235871:T E1283* stop_gained 1.00 0
5:177235863:A W1280* stop_gained 1.00 0
5:177269783:T G1829* stop_gained 1.00 0
5:177294008:T E2214* stop_gained 1.00 0
5:177248292:T G1537* stop_gained 1.00 0
5:177248310:T E1543* stop_gained 1.00 0
5:177293855:T Q2163* stop_gained 1.00 0
5:177269723:T Q1809* stop_gained 1.00 0
5:177260163:G S1714* stop_gained 1.00 0
5:177280589:T Q1883* stop_gained 1.00 0
5:177280742:T Q1934* stop_gained 1.00 0
5:177260163:A S1714* stop_gained 1.00 0
5:177283865:T Q2030* stop_gained 1.00 0
5:177283847:T Q2024* stop_gained 1.00 0
5:177282537:T Q1989* stop_gained 1.00 0
5:177259995:A L1658* stop_gained 1.00 0
5:177248268:T K1529* stop_gained 1.00 0
5:177288909:A L2081* stop_gained 1.00 0
5:177269675:T E1793* stop_gained 1.00 0
5:177248307:T K1542* stop_gained 1.00 0
5:177248271:T K1530* stop_gained 1.00 0
5:177292029:T E2112* stop_gained 1.00 0
5:177280608:A L1889* stop_gained 1.00 0
5:177280608:G L1889* stop_gained 1.00 0
5:177251823:T G1579* stop_gained 1.00 0
5:177294026:T E2220* stop_gained 1.00 0
5:177294017:T E2217* stop_gained 1.00 0
5:177292113:T K2140* stop_gained 1.00 0
5:177292098:T K2135* stop_gained 1.00 0
5:177291978:T K2095* stop_gained 1.00 0
5:177288923:T K2086* stop_gained 1.00 0
5:177288866:T K2067* stop_gained 1.00 0
5:177280754:T K1938* stop_gained 1.00 0
5:177273782:T K1874* stop_gained 1.00 0
5:177273773:T K1871* stop_gained 1.00 0
5:177273758:T K1866* stop_gained 1.00 0
5:177267702:T K1763* stop_gained 1.00 0
5:177267672:T K1753* stop_gained 1.00 0
5:177267669:T K1752* stop_gained 1.00 0
5:177257148:T K1655* stop_gained 1.00 0
5:177257022:T K1613* stop_gained 1.00 0
5:177251841:T E1585* stop_gained 1.00 0
5:177251763:T E1559* stop_gained 1.00 0
5:177251748:T E1554* stop_gained 1.00 0
5:177251736:T E1550* stop_gained 1.00 0
5:177204263:T K403* stop_gained 1.00 0
5:177204290:T K412* stop_gained 1.00 0
5:177283868:T K2031* stop_gained 1.00 0
5:177282579:T K2003* stop_gained 1.00 0
5:177283811:T K2012* stop_gained 1.00 0
5:177204176:T E374* stop_gained 1.00 0
5:177204164:T G370* stop_gained 1.00 0
5:177269801:T K1835* stop_gained 1.00 0
5:177269780:T K1828* stop_gained 1.00 0
5:177204272:T E406* stop_gained 1.00 0
5:177204187:A W377* stop_gained 1.00 0
5:177204186:A W377* stop_gained 1.00 0
5:177273737:T E1859* stop_gained 1.00 0
5:177260149:A W1709* stop_gained 1.00 0
5:177293978:T E2204* stop_gained 1.00 0
5:177293894:T E2176* stop_gained 1.00 0
5:177293930:T E2188* stop_gained 1.00 0
5:177260148:A W1709* stop_gained 1.00 0
5:177280832:T K1964* stop_gained 1.00 0
5:177260129:T E1703* stop_gained 1.00 0
5:177288863:T G2066* stop_gained 1.00 0
5:177283873:A W2032* stop_gained 1.00 0
5:177283883:T G2036* stop_gained 1.00 0
5:177283859:T E2028* stop_gained 1.00 0
5:177283814:T G2013* stop_gained 1.00 0
5:177273680:T E1840* stop_gained 1.00 0
5:177260168:T G1716* stop_gained 1.00 0
5:177269696:T G1800* stop_gained 1.00 0
5:177292041:T E2116* stop_gained 1.00 0
5:177267697:A W1761* stop_gained 1.00 0
5:177269715:A W1806* stop_gained 1.00 0
5:177269716:A W1806* stop_gained 1.00 0
5:177269672:T G1792* stop_gained 1.00 0
5:177273701:T E1847* stop_gained 1.00 0
5:177269615:T E1773* stop_gained 1.00 0
5:177269608:A W1770* stop_gained 1.00 0
5:177269607:A W1770* stop_gained 1.00 0
5:177269605:A W1769* stop_gained 1.00 0
5:177269604:A W1769* stop_gained 1.00 0
5:177267708:T G1765* stop_gained 1.00 0
5:177269747:T E1817* stop_gained 1.00 0
5:177293851:A W2161* stop_gained 1.00 0
5:177293850:A W2161* stop_gained 1.00 0
5:177267698:A W1761* stop_gained 1.00 0
5:177293840:T E2158* stop_gained 1.00 0
5:177267687:T E1758* stop_gained 1.00 0
5:177293839:A W2157* stop_gained 1.00 0
5:177293838:A W2157* stop_gained 1.00 0
5:177292053:T E2120* stop_gained 1.00 0
5:177267644:A W1743* stop_gained 1.00 0
5:177267643:A W1743* stop_gained 1.00 0
5:177267636:T G1741* stop_gained 1.00 0
5:177292047:T E2118* stop_gained 1.00 0
5:177267609:T E1732* stop_gained 1.00 0
5:177280613:T E1891* stop_gained 1.00 0
5:177291975:T E2094* stop_gained 1.00 0
5:177291972:T E2093* stop_gained 1.00 0
5:177280646:T E1902* stop_gained 1.00 0
5:177257019:T G1612* stop_gained 1.00 0
5:177280670:T E1910* stop_gained 1.00 0
5:177280697:T E1919* stop_gained 1.00 0
5:177288884:T G2073* stop_gained 1.00 0
5:177288848:T E2061* stop_gained 1.00 0
5:177282540:T E1990* stop_gained 1.00 0
5:177280804:A W1954* stop_gained 1.00 0
5:177280803:A W1954* stop_gained 1.00 0
5:177282504:T E1978* stop_gained 1.00 0
5:177282492:T E1974* stop_gained 1.00 0
5:177288824:T E2053* stop_gained 1.00 0
5:177282480:T E1970* stop_gained 1.00 0
5:177282510:T E1980* stop_gained 1.00 0
5:177211160:T K921* stop_gained 1.00 0
5:177211142:T K915* stop_gained 1.00 0
5:177238357:T E1348* stop_gained 1.00 0
5:177292008:T G2105* stop_gained 1.00 0
5:177235883:T E1287* stop_gained 1.00 0
5:177211868:T K1157* stop_gained 1.00 0
5:177211871:T K1158* stop_gained 1.00 0
5:177295356:A W2663* stop_gained 1.00 0
5:177295357:A W2663* stop_gained 1.00 0
5:177212042:T E1215* stop_gained 1.00 0
5:177295364:T G2666* stop_gained 1.00 0
5:177246752:T K1485* stop_gained 1.00 0
5:177246758:T K1487* stop_gained 1.00 0
5:177246707:T K1470* stop_gained 1.00 0
5:177246713:T K1472* stop_gained 1.00 0
5:177246698:T K1467* stop_gained 1.00 0
5:177246749:T K1484* stop_gained 1.00 0
5:177246686:T K1463* stop_gained 1.00 0
5:177235864:A W1280* stop_gained 1.00 0
5:177135287:T G62* stop_gained 1.00 0
5:177269654:T K1786* stop_gained 1.00 0
5:177135602:T E167* stop_gained 1.00 0
5:177192008:G S351* stop_gained 1.00 0
5:177210945:G S849* stop_gained 1.00 0
5:177192008:A S351* stop_gained 1.00 0
5:177191887:T Q311* stop_gained 1.00 0
5:177210945:A S849* stop_gained 1.00 0
5:177135179:T E26* stop_gained 1.00 0
5:177135380:T G93* stop_gained 1.00 0
5:177295454:T K2696* stop_gained 1.00 0
5:177238330:T K1339* stop_gained 1.00 0
5:177273746:T K1862* stop_gained 1.00 0
5:177238498:T K1395* stop_gained 1.00 0
5:177212114:T K1239* stop_gained 1.00 0
5:177204257:T R401* stop_gained 1.00 0
5:177291957:T Q2088* stop_gained 1.00 0
5:177239816:A L1418* stop_gained 1.00 0
5:177209826:A L476* stop_gained 1.00 0
5:177239816:G L1418* stop_gained 1.00 0
5:177273713:T Q1851* stop_gained 1.00 0
5:177211535:T K1046* stop_gained 1.00 0
5:177211484:T K1029* stop_gained 1.00 0
5:177211472:T K1025* stop_gained 1.00 0
5:177291987:T K2098* stop_gained 1.00 0
5:177273716:T K1852* stop_gained 1.00 0
5:177210035:T Q546* stop_gained 1.00 0
5:177209832:A S478* stop_gained 1.00 0
5:177209832:G S478* stop_gained 1.00 0
5:177257014:A L1610* stop_gained 1.00 0
5:177135512:T E137* stop_gained 1.00 0
5:177135563:T E154* stop_gained 1.00 0
5:177235835:T K1271* stop_gained 1.00 0
5:177269771:T K1825* stop_gained 1.00 0
5:177248217:T K1512* stop_gained 1.00 0
5:177269712:A L1805* stop_gained 1.00 0
5:177293927:T R2187* stop_gained 1.00 0
5:177191920:T E322* stop_gained 1.00 0
5:177135884:T G261* stop_gained 1.00 0
5:177135848:T E249* stop_gained 1.00 0
5:177135905:T E268* stop_gained 1.00 0
5:177135971:T G290* stop_gained 1.00 0
5:177135992:T G297* stop_gained 1.00 0
5:177136019:T E306* stop_gained 1.00 0
5:177235934:T Q1304* stop_gained 1.00 0
5:177273755:T K1865* stop_gained 1.00 0
5:177256995:T K1604* stop_gained 1.00 0
5:177292011:T K2106* stop_gained 1.00 0
5:177292002:T Q2103* stop_gained 1.00 0
5:177209870:T E491* stop_gained 1.00 0
5:177209684:T E429* stop_gained 1.00 0
5:177239764:T E1401* stop_gained 1.00 0
5:177292005:T Q2104* stop_gained 1.00 0
5:177257049:T K1622* stop_gained 1.00 0
5:177209771:T E458* stop_gained 1.00 0
5:177204233:T E393* stop_gained 1.00 0
5:177248181:T G1500* stop_gained 1.00 0
5:177210368:T E657* stop_gained 1.00 0
5:177135395:T Q98* stop_gained 1.00 0
5:177135329:T Q76* stop_gained 1.00 0
5:177210212:T E605* stop_gained 1.00 0
5:177211019:T E874* stop_gained 1.00 0
5:177210557:T E720* stop_gained 1.00 0
5:177295415:T Q2683* stop_gained 1.00 0
5:177211259:T K954* stop_gained 1.00 0
5:177292023:T Q2110* stop_gained 1.00 0
5:177135644:T E181* stop_gained 1.00 0
5:177210857:T K820* stop_gained 1.00 0
5:177209978:T G527* stop_gained 1.00 0
5:177211887:G L1163* stop_gained 1.00 0
5:177211887:A L1163* stop_gained 1.00 0
5:177210284:T E629* stop_gained 1.00 0
5:177209969:T E524* stop_gained 1.00 0
5:177273734:T Q1858* stop_gained 1.00 0
5:177238433:A L1373* stop_gained 1.00 0
5:177238387:T Q1358* stop_gained 1.00 0
5:177280769:T E1943* stop_gained 1.00 0
5:177135851:T K250* stop_gained 1.00 0
5:177211892:T Q1165* stop_gained 1.00 0
5:177135363:G L87* stop_gained 1.00 0
5:177135363:A L87* stop_gained 1.00 0
5:177135336:A L78* stop_gained 1.00 0
5:177135252:G L50* stop_gained 1.00 0
5:177135252:A L50* stop_gained 1.00 0
5:177295279:A W2637* stop_gained 1.00 0
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5:177210168:G L590* stop_gained 1.00 0
5:177210168:A L590* stop_gained 1.00 0
5:177288883:A C2072* stop_gained 1.00 0
5:177280675:A C1911* stop_gained 1.00 0
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5:177295109:T K2581* stop_gained 1.00 0
5:177211622:T G1075* stop_gained 1.00 0
5:177295391:T Q2675* stop_gained 0.99 0
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5:177294593:T K2409* stop_gained 0.99 0
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5:177280627:A C1895* stop_gained 0.99 0
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5:177210268:G Y623* stop_gained 0.99 0
5:177280657:A C1905* stop_gained 0.99 0
5:177251777:A C1563* stop_gained 0.99 0
5:177211207:A Y936* stop_gained 0.99 0
5:177210316:A C639* stop_gained 0.99 0
5:177244251:A Y1453* stop_gained 0.99 0
5:177280696:A Y1918* stop_gained 0.99 0
5:177280696:G Y1918* stop_gained 0.99 0
5:177295263:A S2632* stop_gained 0.99 0
5:177295263:G S2632* stop_gained 0.99 0
5:177244251:G Y1453* stop_gained 0.99 0
5:177283822:G Y2015* stop_gained 0.99 0
5:177295292:T G2642* stop_gained 0.99 0
5:177283822:A Y2015* stop_gained 0.99 0
5:177280717:A C1925* stop_gained 0.99 0
5:177282533:G Y1987* stop_gained 0.99 0
5:177211634:T R1079* stop_gained 0.99 0
5:177282533:A Y1987* stop_gained 0.99 0
5:177211632:A L1078* stop_gained 0.99 0
5:177248321:A C1546* stop_gained 0.99 0
5:177211604:T Q1069* stop_gained 0.99 0
5:177211207:G Y936* stop_gained 0.99 0
5:177280765:A Y1941* stop_gained 0.99 0
5:177280765:G Y1941* stop_gained 0.99 0
In silico saturation mutagenesis
Alt text Show figure caption
Cancer type Selected cancer type Mutational discovery Index Feature Complexity
(HNSC) Head and neck squamous cell carcinoma HNSC 0.09 0.05