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Note: You're navigating the results of models obtained with the previous release of IntOGen (2020). A new boostDM version corresponding to the current IntOGen release will be available soon.
TP53 17:7674218:C (R249G) × BLCA ×
Driver potential information
Model BoostDM class BoostDM score
(BLCA) Bladder cancer Driver 0.98
Feature importance

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Feature Feature value SHAP value
Linear Clustering Score (LCS) 493.73 -0.28 Medium negative
Linear Clustering in Cancer Type (LCT) 1.00 0.12 Medium positive
Linear Clustering (LC) 0.00 0.12 Medium positive
3D Clustering in Cancer Type (3CT) 1.00 2.73 High positive
3D clustering (3C) 0.00 -0.04 Non-significant
Recurrent in PFAM Domain (DOM) 1.00 0.02 Non-significant
Recurrent in PFAM Domain v2 (DOM2) 0.00 -0.02 Non-significant
PhyloP 100-way Score (PHYLOP) 0.13 -1.04 High negative
Stop Codon in Last Exon (NMD) 0.00 0.00 Non-significant
Post-translational Modification Site: Acetylation (ACETYLATION) 0.00 0.00 Non-significant
Post-translational Modification Site: Methylation (METHYLATION) 0.00 -0.01 Non-significant
Post-translational Modification Site: Phosphorylation (PHOS) 1.00 0.02 Non-significant
Post-translational Modification Site: Regulatory site (REG) 1.00 0.03 Non-significant
Post-translational Modification Site: Ubiquitination (UB) 0.00 0.00 Non-significant
Consequence Type: Missense (MISSENSE) 1.00 0.40 Medium positive
Consequence Type: Nonsense (NONSENSE) 0.00 -0.28 Medium negative
Consequence Type: Splice-affecting (SPLICE) 0.00 -0.09 Non-significant
Consequence Type: Synonymous (SYNONYMOUS) 0.00 0.00 Non-significant