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SMAD4 18:51065515:C (V350L) × ESCA ×
Driver potential information
Model BoostDM class BoostDM score
(ESCA) Esophageal Adenocarcinoma Driver 0.98
Feature importance

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Feature Feature value SHAP value
Linear Clustering Score (LCS) 0.00 -0.02 Non-significant
3D Clustering in Cancer Type (3CT) 1.00 1.10 High positive
Recurrent in PFAM Domain (DOM) 2.00 0.55 Medium positive
PhyloP 100-way Score (PHYLOP) 9.80 0.32 Medium positive
Stop Codon in Last Exon (NMD) 0.00 0.00 Non-significant
Post-translational Modification Site: Acetylation (ACETYLATION) 0.00 0.00 Non-significant
Post-translational Modification Site: Methylation (METHYLATION) 0.00 0.00 Non-significant
Post-translational Modification Site: Phosphorylation (PHOS) 0.00 0.00 Non-significant
Post-translational Modification Site: Regulatory site (REG) 0.00 0.00 Non-significant
Post-translational Modification Site: Ubiquitination (UB) 0.00 0.00 Non-significant
Consequence Type: Missense (MISSENSE) 1.00 -0.04 Non-significant
Consequence Type: Nonsense (NONSENSE) 0.00 -0.23 Medium negative
Consequence Type: Splice-affecting (SPLICE) 0.00 0.00 Non-significant