Top
SMAD4 18:51054898:A (S191*) × ESCA ×
Driver potential information
Model BoostDM class BoostDM score
(ESCA) Esophageal Adenocarcinoma Driver 0.80
Feature importance

Place the mouse pointer over a mutational feature for additional information. See the FAQs for more details about the feature importance.

Feature Feature value SHAP value
Linear Clustering Score (LCS) 0.00 -0.02 Non-significant
3D Clustering in Cancer Type (3CT) 0.00 -0.60 Medium negative
Recurrent in PFAM Domain (DOM) 0.00 -0.69 Medium negative
PhyloP 100-way Score (PHYLOP) 5.37 -0.34 Medium negative
Stop Codon in Last Exon (NMD) 0.00 0.00 Non-significant
Post-translational Modification Site: Acetylation (ACETYLATION) 0.00 0.00 Non-significant
Post-translational Modification Site: Methylation (METHYLATION) 0.00 0.00 Non-significant
Post-translational Modification Site: Phosphorylation (PHOS) 0.00 0.00 Non-significant
Post-translational Modification Site: Regulatory site (REG) 0.00 0.00 Non-significant
Post-translational Modification Site: Ubiquitination (UB) 0.00 0.00 Non-significant
Consequence Type: Missense (MISSENSE) 0.00 0.11 Medium positive
Consequence Type: Nonsense (NONSENSE) 1.00 2.16 High positive
Consequence Type: Splice-affecting (SPLICE) 0.00 0.00 Non-significant