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SMAD4 18:51047216:G (L57*) × ESCA ×
Driver potential information
Model BoostDM class BoostDM score
(ESCA) Esophageal Adenocarcinoma Driver 0.89
Feature importance

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Feature Feature value SHAP value
Linear Clustering Score (LCS) 0.00 -0.02 Non-significant
3D Clustering in Cancer Type (3CT) 0.00 -0.58 Medium negative
Recurrent in PFAM Domain (DOM) 0.00 -0.55 Medium negative
PhyloP 100-way Score (PHYLOP) 8.02 0.06 Non-significant
Stop Codon in Last Exon (NMD) 0.00 0.00 Non-significant
Post-translational Modification Site: Acetylation (ACETYLATION) 0.00 0.00 Non-significant
Post-translational Modification Site: Methylation (METHYLATION) 0.00 0.00 Non-significant
Post-translational Modification Site: Phosphorylation (PHOS) 0.00 0.00 Non-significant
Post-translational Modification Site: Regulatory site (REG) 0.00 0.00 Non-significant
Post-translational Modification Site: Ubiquitination (UB) 0.00 0.00 Non-significant
Consequence Type: Missense (MISSENSE) 0.00 0.13 Medium positive
Consequence Type: Nonsense (NONSENSE) 1.00 1.87 High positive
Consequence Type: Splice-affecting (SPLICE) 0.00 0.00 Non-significant