BoostDM

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Note: You're navigating the results of models obtained with the previous release of IntOGen (2020). A new boostDM version corresponding to the current IntOGen release will be available soon.

KRAS 12:25227339:A (E62V) ×

Driver potential

Model	BoostDM class	BoostDM score
(ALL) Acute lymphoblastic leukemia	Driver	0.72
(BLCA) Bladder cancer	Driver	0.95
(CH) Cholangiocarcinoma	Driver	0.61
(COREAD) Colorectal adenocarcinoma	Passenger	0.01
(LUAD) Lung adenocarcinoma	Passenger	0.02
(LUNG_CANCER) Lung cancer	Passenger	0.00
(MM) Multiple myeloma	Driver	1.00
(OV) Ovary cancer	Passenger	0.22
(PAAD) Pancreas adenocarcinoma	Passenger	0.00
(ST) Stomach adenocarcinoma	Driver	0.91
(UCEC) Endometrial cancer	Passenger	0.43

Select a tumor type to check the corresponding model Show the legend

Predictions cast with a model trained in this specific tumor type.

Predictions cast with a model trained with a more general tumor type, determined as the most recent underlined ancestor of the leaf.

Driver
The mutation is predicted to be a driver in this tumor type context.

Passenger
The mutation is predicted to be a passenger in this tumor type context.

(CANCER) Cancer
- (SOLID) Solid tumour
  - (UCEC) Endometrial cancer
    
    Passenger
  - (ST) Stomach adenocarcinoma
    
    Driver
  - (PA) Pancreatic cancer
    - (PAAD) Pancreas adenocarcinoma
      
      Passenger
  - (OV) Ovary cancer
    
    Passenger
  - (LUNG_CANCER) Lung cancer
    - (NSCLC) Non-small cell lung cancer
      - (LUAD) Lung adenocarcinoma
        
        Passenger
  - (COREAD) Colorectal adenocarcinoma
    
    Passenger
  - (CH) Cholangiocarcinoma
    
    Driver
  - (BLCA) Bladder cancer
    
    Driver
- (NON_SOLID) Non-Solid cancer
  - (MM) Multiple myeloma
    
    Driver
  - (L) Lymphoid cancer
    - (LK) Leukemia
      - (ALL) Acute lymphoblastic leukemia
        
        Driver