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ZNF449 has not been detected as a mutational cancer driver

ZNF449
Ensembl id ENSG00000173275
Mutated samples
Coding Sequence 40 (0.6%)
Protein Affecting 33 (0.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ZNF449 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Uterine corpus endometrioid carcinoma No 5 4 1.74
Head and neck squamous cell carcinoma No 5 4 1.07
Lung adenocarcinoma No 4 3 0.77
Breast carcinoma No 3 3 0.26
Lung squamous cell carcinoma No 3 3 1.72
Cutaneous melanoma No 4 3 0.81
Renal clear cell carcinoma No 2 2 0.48
Serous ovarian adenocarcinoma No 2 2 0.63
Stomach adenocarcinoma No 4 2 1.24
Glioblastoma multiforme No 2 2 0.53
Esophageal carcinoma No 2 2 1.37
Hepatocarcinoma No 1 1 1.11
Chronic lymphocytic leukemia No 1 1 0.34
Multiple myeloma No 1 1 1.45
Colorectal adenocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence