Top
  • Cancer Types
    Projects
    6792 Samples
    1341752 Somatic mutations
  • Coding sequence mutations (CSMs)
    in driver genes 21648
    in all genes 1341706
  • Protein affecting mutations (PAMs)
    in driver genes 18649
    in all genes 603770
IntOGen collects and analyses somatic mutations in thousands of tumor genomes to identify cancer driver genes.

Cancer type Project Samples Cancer drivers PAMs in cancer drivers
Stomach adenocarcinoma STAD_TCGA 139 165 951
Renal clear cell carcinoma RCCC_TCGA 417 105 969
Lung adenocarcinoma LUAD_WUSTL 163 23 247
Glioblastoma multiforme GBM_JHU 89 7 125
Breast carcinoma BRCA_BROAD 103 35 162
Lung squamous cell carcinoma LUSC_TCGA 174 147 1013
Small cell lung carcinoma SCLC_UKOLN 27 29 133
Serous ovarian adenocarcinoma OV_TCGA 316 83 599
Lung adenocarcinoma LUAD_TCGA 228 169 1317
Head and neck squamous cell carcinoma HNSC_BROAD 74 54 215
Cutaneous melanoma CM_TCGA 249 171 2432
Pylocytic astrocytoma PA_SANGER 63 2 8
Acute myeloid leukemia AML_TCGA 196 32 409
Medulloblastoma MB_DKFZ 110 16 78
Chronic lymphocytic leukemia CLL_DFCI 159 21 124
Bladder carcinoma BLCA_TCGA 98 156 954
Breast carcinoma BRCA_SANGER 100 42 225
Breast carcinoma BRCA_WUSTL 76 24 136
Breast carcinoma BRCA_TCGA 762 129 1672
Lower grade glioma LGG_TCGA 169 50 595
Acute lymphocytic leukemia ALL_SANGER 55 2 4
Acute lymphocytic leukemia ALL_STJUDE 38 6 29
Neuroblastoma NB_BROAD 210 27 92
Glioblastoma multiforme GBM_TCGA 290 75 717
Cutaneous melanoma CM_BROAD 120 155 1603
Non small cell lung carcinoma NSCLC_MCW 31 11 47
Head and neck squamous cell carcinoma HNSC_TCGA 301 131 1512
Chronic lymphocytic leukemia CLL_ISCIII 131 26 156
Prostate adenocarcinoma PRAD_TCGA 243 88 372
Small cell lung carcinoma SCLC_JHU 42 45 166
Thyroid carcinoma THCA_TCGA 322 32 316
Pylocytic astrocytoma PA_STJUDE 38 0 0
Colorectal adenocarcinoma COREAD_TCGA 193 89 862
Colorectal adenocarcinoma COREAD_JHU 36 13 93
Esophageal carcinoma ESCA_DFCI 146 98 455
Hepatocarcinoma HC_ICGC 66 28 132
Uterine corpus endometrioid carcinoma UCEC_TCGA 230 149 1784
Diffuse B cell lymphoma DLBC_SANGER 23 10 74
Breast carcinoma BRCA_JHU 42 11 43
Pancreas adenocarcinoma PAAD_QCMG 67 13 112
Stomach adenocarcinoma STAD_PFIZER 22 29 110
Pancreas adenocarcinoma PAAD_OICR 33 3 18
Multiple myeloma MM_SANGER 69 18 97
Medulloblastoma MB_SANGER 100 16 83
Acute lymphocytic leukemia ALL_LEUU 29 4 10
Hepatocarcinoma HC_IACR 24 5 19
Pancreas adenocarcinoma PAAD_JHU 114 14 286
Breast carcinoma BRCA_BCU 65 24 92
This driver cloud represents the most recurrently mutated cancer driver genes. The size of the gene symbol is relative to the count of samples with PAMs.
This plot shows the most recurrently mutated cancer driver genes. Each bar of the histogram indicates the amount of samples with PAMs.

Symbol Ensembl id Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
TP53 ENSG00000141510 2227 2187 32.20
PIK3CA ENSG00000121879 789 747 11.00
KRAS ENSG00000133703 544 533 7.85
PTEN ENSG00000171862 452 440 6.48
BRAF ENSG00000157764 498 472 6.95
APC ENSG00000134982 367 336 4.95
NF1 ENSG00000196712 354 286 4.21
LPHN2 ENSG00000117114 210 132 1.94
CDKN2A ENSG00000147889 246 235 3.46
PIK3R1 ENSG00000145675 205 150 2.21
NRAS ENSG00000213281 234 209 3.08
IDH1 ENSG00000138413 225 217 3.19
CTNNB1 ENSG00000168036 199 184 2.71
NCOR1 ENSG00000141027 179 132 1.94
FBXW7 ENSG00000109670 156 143 2.11
ERBB3 ENSG00000065361 129 102 1.50
FLT3 ENSG00000122025 163 111 1.63
SMAD4 ENSG00000141646 149 128 1.88
SF3B1 ENSG00000115524 144 121 1.78
DNMT3A ENSG00000119772 134 115 1.69
CIC ENSG00000079432 129 99 1.46
FGFR2 ENSG00000066468 120 91 1.34
RUNX1 ENSG00000159216 103 63 0.93
NFE2L2 ENSG00000116044 107 93 1.37
CASP8 ENSG00000064012 97 79 1.16
PPP2R1A ENSG00000105568 70 54 0.80
SPOP ENSG00000121067 64 55 0.81
AKT1 ENSG00000142208 65 52 0.77
HRAS ENSG00000174775 54 48 0.71
IDH2 ENSG00000182054 44 39 0.57
PPP6C ENSG00000119414 39 33 0.49
RAC1 ENSG00000136238 38 28 0.41
U2AF1 ENSG00000160201 35 25 0.37
MLL3 ENSG00000055609 451 391 5.76
MLL2 ENSG00000167548 362 300 4.42
ARID1A ENSG00000117713 321 290 4.27
STAG2 ENSG00000101972 269 97 1.43
ATRX ENSG00000085224 253 209 3.08
ATM ENSG00000149311 237 207 3.05
PBRM1 ENSG00000163939 256 221 3.25
VHL ENSG00000134086 238 227 3.34
RB1 ENSG00000139687 230 192 2.83
NOTCH1 ENSG00000148400 214 165 2.43
CREBBP ENSG00000005339 205 162 2.39
MTOR ENSG00000198793 197 146 2.15
KDR ENSG00000128052 185 143 2.11
SMARCA4 ENSG00000127616 191 154 2.27
CHD4 ENSG00000111642 186 141 2.08
ARID2 ENSG00000189079 176 155 2.28
NSD1 ENSG00000165671 178 125 1.84
SETD2 ENSG00000181555 181 165 2.43
ALK ENSG00000171094 174 125 1.84
MED12 ENSG00000184634 170 138 2.03
MGA ENSG00000174197 162 121 1.78
MAP3K1 ENSG00000095015 136 123 1.81
GATA3 ENSG00000107485 166 145 2.13
CDH1 ENSG00000039068 145 129 1.90
GNAS ENSG00000087460 139 113 1.66
FAM123B ENSG00000184675 126 108 1.59
KDM6A ENSG00000147050 119 105 1.55
BAP1 ENSG00000163930 116 85 1.25
ARID5B ENSG00000150347 109 79 1.16
TET2 ENSG00000168769 99 77 1.13
KEAP1 ENSG00000079999 110 98 1.44
CTCF ENSG00000102974 108 90 1.33
KDM5C ENSG00000126012 104 85 1.25
KIT ENSG00000157404 96 68 1.00
TBX3 ENSG00000135111 92 66 0.97
STK11 ENSG00000118046 84 68 1.00
PRKAR1A ENSG00000108946 86 25 0.37
RGS3 ENSG00000138835 87 66 0.97
ZNF814 ENSG00000204514 85 50 0.74
PTPN11 ENSG00000179295 83 68 1.00
TGFBR2 ENSG00000163513 84 70 1.03
WT1 ENSG00000184937 81 55 0.81
RHOA ENSG00000067560 80 35 0.52
EPHA2 ENSG00000142627 75 60 0.88
RBM10 ENSG00000182872 78 54 0.80
RASA1 ENSG00000145715 77 62 0.91
MAP2K4 ENSG00000065559 77 72 1.06
FGFR1 ENSG00000077782 71 39 0.57
XPO1 ENSG00000082898 63 46 0.68
TCF7L2 ENSG00000148737 72 49 0.72
FUBP1 ENSG00000162613 70 53 0.78
NPM1 ENSG00000181163 67 63 0.93
RPL22 ENSG00000116251 63 43 0.63
ZFP36L1 ENSG00000185650 64 37 0.54
ACVR2A ENSG00000121989 60 48 0.71
FOXA1 ENSG00000129514 61 45 0.66
ELF3 ENSG00000163435 54 32 0.47
MYB ENSG00000118513 56 43 0.63
ZNF750 ENSG00000141579 58 42 0.62
RPSAP58 ENSG00000205246 58 40 0.59
HLA-A ENSG00000206503 56 39 0.57
SMAD2 ENSG00000175387 56 45 0.66
PABPC1 ENSG00000070756 55 40 0.59
TBL1XR1 ENSG00000177565 51 38 0.56
SMO ENSG00000128602 52 45 0.66
CNOT4 ENSG00000080802 49 32 0.47
MAP2K1 ENSG00000169032 51 39 0.57
EPC1 ENSG00000120616 50 35 0.52
MAX ENSG00000125952 50 21 0.31
TXNIP ENSG00000117289 46 24 0.35
SOX9 ENSG00000125398 47 37 0.54
PHF6 ENSG00000156531 47 40 0.59
SCAI ENSG00000173611 48 36 0.53
RPL5 ENSG00000122406 45 32 0.47
FRG1 ENSG00000109536 44 26 0.38
ACTG1 ENSG00000184009 43 37 0.54
CBFB ENSG00000067955 39 33 0.49
CDKN1A ENSG00000124762 38 28 0.41
CCND1 ENSG00000110092 34 21 0.31
CLCC1 ENSG00000121940 35 24 0.35
B2M ENSG00000166710 36 25 0.37
CDKN1B ENSG00000111276 34 32 0.47
CSNK2A1 ENSG00000101266 31 26 0.38
MYD88 ENSG00000172936 34 26 0.38
CEBPA ENSG00000245848 19 13 0.19
EIF1AX ENSG00000173674 20 19 0.28
ANK3 ENSG00000151150 348 268 3.95
MACF1 ENSG00000127603 390 265 3.90
AHNAK ENSG00000124942 328 247 3.64
LAMA2 ENSG00000196569 322 244 3.59
ROBO2 ENSG00000185008 235 156 2.30
FAT2 ENSG00000086570 295 218 3.21
KALRN ENSG00000160145 258 184 2.71
SVEP1 ENSG00000165124 255 198 2.92
FIP1L1 ENSG00000145216 269 77 1.13
ZFHX3 ENSG00000140836 269 193 2.84
ASPM ENSG00000066279 233 186 2.74
AKAP9 ENSG00000127914 232 189 2.78
PLCB1 ENSG00000182621 197 143 2.11
MECOM ENSG00000085276 189 142 2.09
PCSK5 ENSG00000099139 182 134 1.97
F8 ENSG00000185010 193 151 2.22
PCDH18 ENSG00000189184 186 153 2.25
MLL ENSG00000118058 197 155 2.28
MAGI2 ENSG00000187391 187 118 1.74
BRCA2 ENSG00000139618 196 151 2.22
CHD6 ENSG00000124177 192 140 2.06
TRIO ENSG00000038382 185 128 1.88
BCLAF1 ENSG00000029363 170 143 2.11
HDAC9 ENSG00000048052 164 104 1.53
NOTCH2 ENSG00000134250 171 130 1.91
FN1 ENSG00000115414 172 134 1.97
WNK1 ENSG00000060237 167 115 1.69
ATR ENSG00000175054 166 136 2.00
ACACA ENSG00000132142 167 107 1.58
MYH9 ENSG00000100345 158 99 1.46
SPTAN1 ENSG00000197694 157 101 1.49
EP300 ENSG00000100393 152 134 1.97
CUX1 ENSG00000257923 147 96 1.41
BAZ2B ENSG00000123636 145 117 1.72
ARAP3 ENSG00000120318 149 58 0.85
NCOR2 ENSG00000196498 143 102 1.50
ADCY1 ENSG00000164742 136 101 1.49
ARID1B ENSG00000049618 142 106 1.56
CAD ENSG00000084774 146 103 1.52
ARFGEF1 ENSG00000066777 132 80 1.18
PRPF8 ENSG00000174231 135 88 1.30
BCOR ENSG00000183337 136 105 1.55
COL1A1 ENSG00000108821 131 103 1.52
PLXNA1 ENSG00000114554 132 82 1.21
CHD8 ENSG00000100888 131 103 1.52
FBXO11 ENSG00000138081 131 50 0.74
BPTF ENSG00000171634 134 108 1.59
ERBB2 ENSG00000141736 127 89 1.31
PTCH1 ENSG00000185920 134 97 1.43
PLXNB2 ENSG00000196576 128 81 1.19
PTPRF ENSG00000142949 120 89 1.31
ZNF292 ENSG00000188994 132 107 1.58
ARHGAP35 ENSG00000160007 122 111 1.63
HCFC1 ENSG00000172534 127 83 1.22
NUP98 ENSG00000110713 127 77 1.13
C15orf55 ENSG00000184507 120 74 1.09
BRWD1 ENSG00000185658 121 93 1.37
KAT6B ENSG00000156650 126 91 1.34
BCL11A ENSG00000119866 124 76 1.12
BRCA1 ENSG00000012048 119 95 1.40
MSR1 ENSG00000038945 110 70 1.03
EPHB2 ENSG00000133216 113 75 1.10
CHD9 ENSG00000177200 122 102 1.50
INPPL1 ENSG00000165458 116 71 1.05
MYH10 ENSG00000133026 115 92 1.35
TAOK2 ENSG00000149930 112 69 1.02
ARID4B ENSG00000054267 115 67 0.99
MYH14 ENSG00000105357 119 85 1.25
PTPRU ENSG00000060656 114 93 1.37
USP6 ENSG00000129204 116 84 1.24
ARHGAP29 ENSG00000137962 106 79 1.16
DICER1 ENSG00000100697 110 90 1.33
CNTNAP1 ENSG00000108797 110 71 1.05
CHD3 ENSG00000170004 110 79 1.16
EIF4G3 ENSG00000075151 110 83 1.22
ZNF638 ENSG00000075292 112 84 1.24
EIF4G1 ENSG00000114867 98 70 1.03
EPHA4 ENSG00000116106 104 67 0.99
MLLT4 ENSG00000130396 111 69 1.02
CDK12 ENSG00000167258 105 90 1.33
TRERF1 ENSG00000124496 97 62 0.91
PIK3C2B ENSG00000133056 105 80 1.18
STAG1 ENSG00000118007 104 83 1.22
SRGAP1 ENSG00000196935 105 71 1.05
DDX3X ENSG00000215301 101 93 1.37
TP53BP1 ENSG00000067369 108 85 1.25
AXIN1 ENSG00000103126 99 52 0.77
ASXL1 ENSG00000171456 104 75 1.10
BLM ENSG00000197299 96 81 1.19
AHCTF1 ENSG00000153207 107 84 1.24
IRF7 ENSG00000185507 103 18 0.27
WHSC1 ENSG00000109685 101 62 0.91
ABL2 ENSG00000143322 101 67 0.99
EPHA1 ENSG00000146904 101 67 0.99
TCF4 ENSG00000196628 96 62 0.91
XRN1 ENSG00000114127 101 78 1.15
MED23 ENSG00000112282 99 59 0.87
MAP4K1 ENSG00000104814 93 52 0.77
MAP3K4 ENSG00000085511 93 74 1.09
STARD13 ENSG00000133121 92 60 0.88
NTRK2 ENSG00000148053 94 59 0.87
POM121 ENSG00000196313 90 52 0.77
WHSC1L1 ENSG00000147548 89 67 0.99
AQR ENSG00000021776 87 69 1.02
CLTC ENSG00000141367 81 52 0.77
PABPC3 ENSG00000151846 85 64 0.94
FCRL4 ENSG00000163518 85 65 0.96
PGR ENSG00000082175 83 56 0.82
CIITA ENSG00000179583 83 55 0.81
MNDA ENSG00000163563 82 68 1.00
ARHGEF2 ENSG00000116584 83 45 0.66
FANCI ENSG00000140525 79 48 0.71
SMC1A ENSG00000072501 80 66 0.97
IRF6 ENSG00000117595 83 49 0.72
HNF1A ENSG00000135100 74 45 0.66
EIF2AK3 ENSG00000172071 74 65 0.96
MLH3 ENSG00000119684 75 50 0.74
PLCG1 ENSG00000124181 78 57 0.84
ITGA9 ENSG00000144668 73 50 0.74
CRNKL1 ENSG00000101343 74 57 0.84
ARID4A ENSG00000032219 74 59 0.87
EFTUD2 ENSG00000108883 75 46 0.68
RFC4 ENSG00000163918 74 21 0.31
MAP3K11 ENSG00000173327 69 27 0.40
SMARCA1 ENSG00000102038 75 50 0.74
RPGR ENSG00000156313 72 51 0.75
MMP2 ENSG00000087245 70 45 0.66
CHEK2 ENSG00000183765 70 52 0.77
CNOT3 ENSG00000088038 70 40 0.59
DHX9 ENSG00000135829 72 60 0.88
MYC ENSG00000136997 44 35 0.52
TSC1 ENSG00000165699 72 44 0.65
TRIP10 ENSG00000125733 68 28 0.41
SEC31A ENSG00000138674 69 47 0.69
CCAR1 ENSG00000060339 69 56 0.82
LRPPRC ENSG00000138095 64 51 0.75
CTNND1 ENSG00000198561 67 48 0.71
INPP4A ENSG00000040933 66 47 0.69
EZH2 ENSG00000106462 68 59 0.87
ZMYM2 ENSG00000121741 59 49 0.72
CUL3 ENSG00000036257 66 53 0.78
ACVR1B ENSG00000135503 64 55 0.81
PER1 ENSG00000179094 65 43 0.63
LIMA1 ENSG00000050405 65 40 0.59
VIM ENSG00000026025 61 45 0.66
NUP93 ENSG00000102900 63 48 0.71
ARHGEF6 ENSG00000129675 63 54 0.80
SYK ENSG00000165025 63 45 0.66
CUL1 ENSG00000055130 60 53 0.78
ERBB2IP ENSG00000112851 57 43 0.63
APAF1 ENSG00000120868 62 48 0.71
AXIN2 ENSG00000168646 59 44 0.65
NEDD4L ENSG00000049759 60 41 0.60
CYLD ENSG00000083799 60 45 0.66
ERCC2 ENSG00000104884 61 34 0.50
TNPO2 ENSG00000105576 59 39 0.57
RASA2 ENSG00000155903 60 48 0.71
FGFR3 ENSG00000068078 56 47 0.69
SMARCB1 ENSG00000099956 58 32 0.47
TAOK1 ENSG00000160551 59 48 0.71
LNPEP ENSG00000113441 51 38 0.56
WASF3 ENSG00000132970 56 42 0.62
SEC24D ENSG00000150961 56 46 0.68
PSME3 ENSG00000131467 56 18 0.27
GPS2 ENSG00000132522 56 22 0.32
DHX35 ENSG00000101452 53 33 0.49
PRKCZ ENSG00000067606 55 31 0.46
MEF2C ENSG00000081189 53 34 0.50
TJP2 ENSG00000119139 50 42 0.62
CDK4 ENSG00000135446 52 22 0.32
RAD21 ENSG00000164754 52 43 0.63
RASGRP1 ENSG00000172575 51 36 0.53
CRTC3 ENSG00000140577 50 32 0.47
NTN4 ENSG00000074527 49 38 0.56
ACTB ENSG00000075624 45 29 0.43
CTTN ENSG00000085733 49 35 0.52
MCM3 ENSG00000112118 46 35 0.52
MYCN ENSG00000134323 49 36 0.53
FAF1 ENSG00000185104 46 30 0.44
ELF4 ENSG00000102034 46 24 0.35
PAX5 ENSG00000196092 45 30 0.44
FOXA2 ENSG00000125798 45 31 0.46
FAM46C ENSG00000183508 44 31 0.46
CYTH4 ENSG00000100055 43 22 0.32
TFDP1 ENSG00000198176 45 37 0.54
SMURF2 ENSG00000108854 41 27 0.40
EEF1B2 ENSG00000114942 35 25 0.37
PSIP1 ENSG00000164985 44 33 0.49
ACTG2 ENSG00000163017 41 28 0.41
IRF2 ENSG00000168310 42 34 0.50
PSMD11 ENSG00000108671 40 17 0.25
MCM8 ENSG00000125885 38 28 0.41
G3BP1 ENSG00000145907 41 25 0.37
RBBP7 ENSG00000102054 38 23 0.34
RHOT1 ENSG00000126858 39 28 0.41
JMY ENSG00000152409 38 27 0.40
MAT2A ENSG00000168906 38 15 0.22
ARFGAP3 ENSG00000242247 36 26 0.38
COPS2 ENSG00000166200 36 29 0.43
DEPDC1B ENSG00000035499 36 28 0.41
ACSL3 ENSG00000123983 33 27 0.40
HLA-B ENSG00000234745 31 28 0.41
ING1 ENSG00000153487 33 26 0.38
WNT5A ENSG00000114251 32 20 0.29
SPRR3 ENSG00000163209 32 17 0.25
MGMT ENSG00000170430 31 15 0.22
PPM1D ENSG00000170836 31 24 0.35
CDC27 ENSG00000004897 27 18 0.27
SH2B3 ENSG00000111252 28 13 0.19
SOX17 ENSG00000164736 28 21 0.31
FKBP5 ENSG00000096060 26 21 0.31
MFNG ENSG00000100060 25 19 0.28
NKX3-1 ENSG00000167034 24 18 0.27
PCBP1 ENSG00000169564 18 12 0.18
EGFR ENSG00000146648 299 228 3.36
FAT1 ENSG00000083857 341 277 4.08
DDX5 ENSG00000108654 65 43 0.63
EEF1A1 ENSG00000156508 47 40 0.59
CSDE1 ENSG00000009307 264 52 0.77
ASH1L ENSG00000116539 169 124 1.83
MYH11 ENSG00000133392 174 126 1.86
TAF1 ENSG00000147133 157 129 1.90
CNOT1 ENSG00000125107 151 99 1.46
HGF ENSG00000019991 136 106 1.56
SETDB1 ENSG00000143379 120 76 1.12
BNC2 ENSG00000173068 118 81 1.19
ARFGEF2 ENSG00000124198 112 89 1.31
MET ENSG00000105976 111 84 1.24
CEP290 ENSG00000198707 113 86 1.27
MUC20 ENSG00000176945 98 30 0.44
LRP6 ENSG00000070018 105 83 1.22
TJP1 ENSG00000104067 106 83 1.22
ITSN1 ENSG00000205726 106 72 1.06
MKL1 ENSG00000196588 93 46 0.68
SRGAP3 ENSG00000196220 93 65 0.96
SIN3A ENSG00000169375 92 70 1.03
PIK3CB ENSG00000051382 87 71 1.05
ACSL6 ENSG00000164398 86 62 0.91
MLH1 ENSG00000076242 85 35 0.52
SOS1 ENSG00000115904 90 79 1.16
AFF4 ENSG00000072364 86 58 0.85
POLR2B ENSG00000047315 84 50 0.74
MED24 ENSG00000008838 74 38 0.56
HSP90AB1 ENSG00000096384 82 41 0.60
FOXP1 ENSG00000114861 78 51 0.75
SOS2 ENSG00000100485 76 55 0.81
EIF4A2 ENSG00000156976 79 39 0.57
CLSPN ENSG00000092853 75 51 0.75
NUP107 ENSG00000111581 68 43 0.63
CLASP2 ENSG00000163539 71 55 0.81
MAP4K3 ENSG00000011566 69 56 0.82
NFATC4 ENSG00000100968 68 54 0.80
PCSK6 ENSG00000140479 65 50 0.74
ARHGAP26 ENSG00000145819 63 42 0.62
ACO1 ENSG00000122729 64 50 0.74
THRAP3 ENSG00000054118 60 51 0.75
NCF2 ENSG00000116701 65 46 0.68
CDC73 ENSG00000134371 63 37 0.54
CASP1 ENSG00000137752 62 23 0.34
BMPR2 ENSG00000204217 59 50 0.74
NCKAP1 ENSG00000061676 62 48 0.71
DLG1 ENSG00000075711 60 46 0.68
WIPF1 ENSG00000115935 60 41 0.60
DIS3 ENSG00000083520 59 41 0.60
IREB2 ENSG00000136381 59 48 0.71
NR4A2 ENSG00000153234 59 46 0.68
PTGS1 ENSG00000095303 56 42 0.62
AHR ENSG00000106546 56 48 0.71
TCF12 ENSG00000140262 55 43 0.63
HSPA8 ENSG00000109971 54 37 0.54
FXR1 ENSG00000114416 56 38 0.56
SYNCRIP ENSG00000135316 55 36 0.53
RTN4 ENSG00000115310 53 45 0.66
CAT ENSG00000121691 52 32 0.47
HDAC3 ENSG00000171720 54 22 0.32
MEN1 ENSG00000133895 52 30 0.44
DHX15 ENSG00000109606 50 31 0.46
EIF2C3 ENSG00000126070 49 39 0.57
CHD1L ENSG00000131778 51 44 0.65
CLOCK ENSG00000134852 48 35 0.52
HSP90AA1 ENSG00000080824 46 31 0.46
LCP1 ENSG00000136167 51 39 0.57
FMR1 ENSG00000102081 49 42 0.62
ADAM10 ENSG00000137845 49 36 0.53
CARM1 ENSG00000142453 50 29 0.43
ZC3H11A ENSG00000058673 46 39 0.57
GPSM2 ENSG00000121957 41 26 0.38
ZFP36L2 ENSG00000152518 47 33 0.49
ELF1 ENSG00000120690 46 33 0.49
ATIC ENSG00000138363 46 34 0.50
CAST ENSG00000153113 44 24 0.35
TNPO1 ENSG00000083312 43 34 0.50
PRRX1 ENSG00000116132 42 28 0.41
UPF3B ENSG00000125351 40 36 0.53
PIP5K1A ENSG00000143398 40 31 0.46
RBM5 ENSG00000003756 39 31 0.46
GOLGA5 ENSG00000066455 42 34 0.50
SUZ12 ENSG00000178691 41 34 0.50
NF2 ENSG00000186575 41 33 0.49
CUL2 ENSG00000108094 39 34 0.50
PIK3R3 ENSG00000117461 39 21 0.31
CCT5 ENSG00000150753 35 26 0.38
CAPN7 ENSG00000131375 35 21 0.31
STIP1 ENSG00000168439 36 25 0.37
FUS ENSG00000089280 33 15 0.22
TOM1 ENSG00000100284 37 27 0.40
NDRG1 ENSG00000104419 36 29 0.43
MED17 ENSG00000042429 34 28 0.41
ARNTL ENSG00000133794 36 27 0.40
KLF6 ENSG00000067082 32 23 0.34
TFDP2 ENSG00000114126 35 25 0.37
ACAD8 ENSG00000151498 34 21 0.31
G3BP2 ENSG00000138757 34 28 0.41
HNRPDL ENSG00000152795 34 28 0.41
NAP1L1 ENSG00000187109 32 18 0.27
GNAI1 ENSG00000127955 32 22 0.32
CSDA ENSG00000060138 31 23 0.34
CSNK1G3 ENSG00000151292 30 23 0.34
PPP2R5A ENSG00000066027 29 18 0.27
PPP2R5C ENSG00000078304 27 21 0.31
HLF ENSG00000108924 29 23 0.34
KLF4 ENSG00000136826 29 25 0.37
NCK1 ENSG00000158092 29 22 0.32
NR2F2 ENSG00000185551 28 23 0.34
STK4 ENSG00000101109 26 22 0.32
ARFGAP1 ENSG00000101199 28 17 0.25
RHEB ENSG00000106615 27 21 0.31
IRS2 ENSG00000185950 24 19 0.28
LDHA ENSG00000134333 23 15 0.22
SHMT1 ENSG00000176974 23 16 0.24
SF3A3 ENSG00000183431 22 19 0.28
SFPQ ENSG00000116560 22 17 0.25
RAD23B ENSG00000119318 22 16 0.24
FAS ENSG00000026103 20 19 0.28
YBX1 ENSG00000065978 18 16 0.24
GNA11 ENSG00000088256 20 16 0.24
PSMA6 ENSG00000100902 19 15 0.22
ATF1 ENSG00000123268 19 17 0.25
GNG2 ENSG00000186469 17 12 0.18
ATP6AP2 ENSG00000182220 14 14 0.21
This plot shows the top 30 driver or known mutations

Mutation Mutated samples % Mutated samples
BRAF V600E 361 5.32
PIK3CA H1047R 191 2.81
KRAS G12D 159 2.34
IDH1 R132H 150 2.21
PIK3CA E545K 139 2.05
KRAS G12V 126 1.86
PIK3CA E542K 82 1.21
TP53 SpliceAcceptorSNV 79 1.16
NRAS Q61R 79 1.16
TP53 R175H 78 1.15
KRAS G12C 73 1.07
TP53 R273C 72 1.06
TP53 SpliceDonorSNV 70 1.03
TP53 R248W 62 0.91
TP53 R273H 61 0.90
TP53 R248Q 59 0.87
NRAS Q61K 53 0.78
TP53 Y220C 42 0.62
TP53 R213* 41 0.60
TP53 R282W 39 0.57
TP53 R196* 38 0.56
AKT1 E17K 34 0.50
TP53 G245S 33 0.49
PIK3CA H1047L 31 0.46
SF3B1 K700E 31 0.46
CDKN2A R80* 30 0.44
KRAS G12R 30 0.44
RPSAP58 Q111E 29 0.43
IDH1 R132C 29 0.43
PIK3CA N345K 29 0.43
PTEN R130G 28 0.41
TP53 R306* 28 0.41
KRAS G13D 27 0.40
KRAS G12A 24 0.35
TP53 H179R 24 0.35
NRAS Q61L 22 0.32
NPM1 W288Lfs 22 0.32
DNMT3A R882H 22 0.32
CDKN2A W110* 21 0.31
NF1 SpliceAcceptorSNV 21 0.31
BRAF V600K 21 0.31
RB1 SpliceAcceptorSNV 20 0.29
NPM1 Q289Sfs 20 0.29
TP53 H193R 20 0.29
EGFR L858R 20 0.29
PIK3CA R88Q 19 0.28
RB1 SpliceDonorSNV 19 0.28
PTEN T319*fs 19 0.28
TP53 Y163C 19 0.28
PTEN R233* 18 0.27
TP53 V157F 18 0.27
KRAS Q61H 18 0.27
PTEN SpliceAcceptorSNV 18 0.27
TP53 R342* 18 0.27
CTNNB1 S37F 17 0.25
APC R1450* 17 0.25
TP53 T125T 17 0.25
TP53 I195T 17 0.25
EGFR G598V 17 0.25
PIK3CA C420R 17 0.25
EGFR A289V 17 0.25
CTNNB1 S33C 16 0.24
PTEN R130Q 16 0.24
PIK3CA G118D 16 0.24
EEF1B2 S43G 16 0.24
IDH2 R140Q 16 0.24
ACVR2A K437Rfs 16 0.24
TP53 C176F 15 0.22
TP53 Y234C 15 0.22
CDKN2A R58* 14 0.21
TP53 C238Y 14 0.21
TP53 V216M 14 0.21
TP53 S241F 14 0.21
TP53 R273L 14 0.21
FBXW7 R465H 14 0.21
APC R876* 13 0.19
MYD88 L265P 13 0.19
U2AF1 S34F 13 0.19
PIK3CA Q546K 13 0.19
ATM SpliceAcceptorSNV 13 0.19
TP53 E285K 12 0.18
PBRM1 SpliceAcceptorSNV 12 0.18
PIK3CA Q546R 12 0.18
CTNNB1 S37C 12 0.18
PIK3CA E453K 12 0.18
TP53 M237I 12 0.18
TP53 Q192* 12 0.18
PIK3CA E726K 12 0.18
PTEN R130* 12 0.18
TP53 G245D 12 0.18
FBXW7 R505C 11 0.16
CTNNB1 S33F 11 0.16
TP53 H214R 11 0.16
TP53 K132N 11 0.16
PTEN SpliceDonorSNV 11 0.16
KRAS G13C 11 0.16
KRAS G12S 11 0.16
TP53 Q317* 11 0.16
TP53 G266V 11 0.16
FLT3 D835Y 11 0.16
HRAS Q61R 11 0.16
TP53 V272M 10 0.15
KRAS A146T 10 0.15
CTNNB1 G34R 10 0.15
TP53 Q331* 10 0.15
FBXW7 R505G 10 0.15
TP53 C275Y 10 0.15
TP53 C238F 10 0.15
CDKN2A SpliceAcceptorSNV 10 0.15
SMAD4 R361H 10 0.15
PIK3R1 G376R 10 0.15
TP53 H179Y 10 0.15
RAC1 P29S 10 0.15
BRAF K601E 10 0.15
PIK3CA E110delE 10 0.15
CDKN2A E120* 10 0.15
TP53 E298* 10 0.15
TP53 R249S 9 0.13
PIK3CA M1043V 9 0.13
NOTCH1 E2515Vfs 9 0.13
CTNNB1 D32Y 9 0.13
FGFR2 S252W 9 0.13
GATA3 P409Afs 9 0.13
TP53 R280K 9 0.13
TP53 C242F 9 0.13
TP53 P278S 9 0.13
PPP6C R301C 9 0.13
TP53 C176Y 9 0.13
VHL SpliceAcceptorSNV 9 0.13
FBXW7 R465C 9 0.13
TP53 R158L 9 0.13
ERBB2 S310F 9 0.13
TP53 Y236C 9 0.13
TP53 V173L 9 0.13
XPO1 E571K 8 0.12
TP53 R158H 8 0.12
TP53 G266* 8 0.12
NRAS G12D 8 0.12
NRAS Q61H 8 0.12
TP53 H193L 8 0.12
PIK3R1 SpliceAcceptorSNV 8 0.12
VHL SpliceDonorSNV 8 0.12
PIK3CA M1043I 8 0.12
TP53 Y205C 8 0.12
TP53 E271K 8 0.12
TP53 G245V 8 0.12
APC R213* 8 0.12
NFE2L2 E79Q 8 0.12
PTEN R335* 8 0.12
PIK3CA R108H 8 0.12
CDKN2A P114L 8 0.12
PPP2R1A P179R 8 0.12
TP53 P250L 8 0.12
TP53 R110L 8 0.12
UBR5 E2121Kfs 8 0.12
CTCF R448* 8 0.12
FGFR2 N550K 8 0.12
CTNNB1 T41A 7 0.10
CLOCK L123*fs 7 0.10
FGFR3 S249C 7 0.10
TP53 C242Afs 7 0.10
KDM6A SpliceAcceptorSNV 7 0.10
SCAI Q155H 7 0.10
DNMT3A R882C 7 0.10
TP53 L194R 7 0.10
TP53 E286K 7 0.10
PTEN SpliceDonorDeletion 7 0.10
IDH2 R172K 7 0.10
NFE2L2 R34G 7 0.10
KRAS Q61R 7 0.10
GNAS R201C 7 0.10
MLL3 SpliceAcceptorSNV 7 0.10
CHD4 R975H 7 0.10
APC R216* 7 0.10
TP53 R249G 7 0.10
NF1 SpliceDonorSNV 7 0.10
IDH1 R132G 7 0.10
SETD2 SpliceDonorSNV 7 0.10
TP53 R337C 7 0.10
ALK R1275Q 7 0.10
PIK3R1 SpliceDonorDeletion 7 0.10
TP53 E198* 7 0.10
PIK3CA K111N 7 0.10
HRAS Q61K 7 0.10
TP53 G266E 7 0.10
FANCD2 SpliceDonorDeletion 7 0.10
PIK3CA E81K 7 0.10
TP53 V173M 7 0.10
ALK F1174L 7 0.10
PIK3CA E545G 7 0.10
IDH1 R132S 7 0.10
PIK3CA E545A 7 0.10
KRAS Q61L 7 0.10
VHL S65* 7 0.10
CR1 R2194* 7 0.10
CDKN2A H83Y 7 0.10
VHL L89H 7 0.10
CDH1 SpliceDonorSNV 7 0.10
MYCN P44L 7 0.10
KDR S1100F 7 0.10
TP53 T155P 7 0.10
NFE2L2 D29H 7 0.10
MAP2K1 P124S 7 0.10
TP53 P152L 7 0.10
MLL2 SpliceDonorSNV 6 0.09
PTEN R130P 6 0.09
CTNNB1 D32N 6 0.09
TP53 R280T 6 0.09
SF3B1 G742D 6 0.09
PIK3CA G1049R 6 0.09
MLL2 SpliceAcceptorSNV 6 0.09
NRAS G13D 6 0.09
ARID1A R1335* 6 0.09
ATRX R1426* 6 0.09
CHD8 SpliceAcceptorSNV 6 0.09
EP300 D1399N 6 0.09
TRRAP S722F 6 0.09
KDM6A Q555* 6 0.09
ERBB2 R678Q 6 0.09
TP53 I255F 6 0.09
TP53 G266R 6 0.09
ERBB2 V842I 6 0.09
TP53 E204* 6 0.09
TP53 R249M 6 0.09
MAX R60Q 6 0.09
TP53 S127F 6 0.09
LRPPRC SpliceAcceptorSNV 6 0.09
ARFGAP3 N299Mfs 6 0.09
APC R805* 6 0.09
HIST1H3B E74K 6 0.09
NOTCH1 SpliceDonorSNV 6 0.09
PIK3CA R93Q 6 0.09
TP53 C275F 6 0.09
TP53 A159V 6 0.09
NRAS G13R 6 0.09
PTPRB D1778N 6 0.09
TP53 V73Wfs 6 0.09
STAG2 SpliceDonorSNV 6 0.09
ARID1A R693* 6 0.09
TP53 C135F 6 0.09
TP53 C141Y 6 0.09
EGFR A289T 6 0.09
TP53 R213Q 6 0.09
TP53 D259Y 5 0.07
KDM6A SpliceDonorSNV 5 0.07
FAT1 SpliceAcceptorSNV 5 0.07
ARID1A R1989* 5 0.07
CLCC1 P406Q 5 0.07
VHL S68* 5 0.07
TP53 P151H 5 0.07
RQCD1 P131L 5 0.07
RHOA E40Q 5 0.07
PTEN Q298* 5 0.07
MGA R2435Q 5 0.07
RNF43 G659Vfs 5 0.07
TP53 P151S 5 0.07
CSNK2A1 H236R 5 0.07
BAP1 SpliceDonorSNV 5 0.07
PTPN11 G503V 5 0.07
PTEN P248Tfs 5 0.07
TP53 G245C 5 0.07
ERBB3 V104M 5 0.07
HRAS G12D 5 0.07
CTNNB1 S45F 5 0.07
CEP290 I556Nfs 5 0.07
TP53 S215R 5 0.07
ING1 R339* 5 0.07
CDKN2A E88* 5 0.07
PABPC3 A313Rfs 5 0.07
TP53 D281Y 5 0.07
TP53 G154Afs 5 0.07
TP53 D281N 5 0.07
PIK3CA R38H 5 0.07
PIK3CA K111E 5 0.07
PIK3CA Q546P 5 0.07
PIK3CA N1044K 5 0.07
FBXW7 R479Q 5 0.07
TP53 C277F 5 0.07
VHL S111N 5 0.07
TP53 E294* 5 0.07
FLT3 D600_L601insSENMNMI 5 0.07
TP53 H193Y 5 0.07
NRAS G12C 5 0.07
KDM6A SpliceDonorDeletion 5 0.07
TP53 Q136* 5 0.07
SPOP F133L 5 0.07
TP53 R280I 5 0.07
PTEN R130L 5 0.07
POLE SpliceAcceptorSNV 5 0.07
ARID1A R1276* 5 0.07
TP53 Q104* 5 0.07
TP53 G244D 5 0.07
CARM1 A202V 5 0.07
TP53 Q144* 5 0.07
TP53 SpliceAcceptorDeletion 5 0.07
TP53 R337L 5 0.07
TP53 V274A 5 0.07
PPP2R1A R183W 5 0.07
TP53 W91* 5 0.07
ARID2 S297F 5 0.07
TP53 A161T 5 0.07
TP53 S127Y 5 0.07
TP53 N239S 5 0.07
ZFHX3 R1893Gfs 5 0.07
TP53 R267P 5 0.07
BRAF G466V 5 0.07
MUC4 H4205Q 5 0.07
TP53 G244C 5 0.07
EGFR R222C 5 0.07
KRAS G12F 5 0.07
TP53 P278L 5 0.07
SMAD4 R361C 5 0.07
HERC2 SpliceDonorSNV 5 0.07
PBRM1 SpliceDonorSNV 5 0.07
TP53 P177R 5 0.07
CTNNB1 G34E 5 0.07
SMARCA4 G1232S 5 0.07
APC R564* 4 0.06
APC SpliceAcceptorSNV 4 0.06
ATRX SpliceAcceptorSNV 4 0.06
STK11 SpliceAcceptorSNV 4 0.06
PTEN A328Qfs 4 0.06
PIK3CA C901F 4 0.06
TP53 E221* 4 0.06
TP53 W146* 4 0.06
CDH1 SpliceAcceptorSNV 4 0.06
APC Q1367* 4 0.06
EGFR L861Q 4 0.06
SMO L412F 4 0.06
ERBB2 D769Y 4 0.06
TP53 T155N 4 0.06
TP53 A159P 4 0.06
TP53 P278R 4 0.06
TP53 C229Yfs 4 0.06
TP53 E285* 4 0.06
NF1 K1661Gfs 4 0.06
FBXW7 G423V 4 0.06
TP53 P27Lfs 4 0.06
TP53 R156P 4 0.06
CREBBP R1446C 4 0.06
PIK3R1 K567E 4 0.06
TP53 R158G 4 0.06
MAP2K1 E203K 4 0.06
CR1 E2220* 4 0.06
TP53 H193P 4 0.06
SPEN R806Tfs 4 0.06
RUNX1 R201* 4 0.06
B2M L15Ffs 4 0.06
PTEN Y27D 4 0.06
MED12 L1224F 4 0.06
EIF2AK3 R911Efs 4 0.06
TP53 L130F 4 0.06
TP53 E224D 4 0.06
CUL3 SpliceAcceptorSNV 4 0.06
TP53 Q167* 4 0.06
CTNNB1 S37A 4 0.06
TP53 V122Dfs 4 0.06
CDKN2A D84N 4 0.06
MAP2K4 S184L 4 0.06
TP53 F134L 4 0.06
CTNNB1 S37Y 4 0.06
SMARCA1 SpliceAcceptorSNV 4 0.06
ARID2 SpliceDonorSNV 4 0.06
CTNNB1 S33Y 4 0.06
KIT D816V 4 0.06
PTEN S170N 4 0.06
SMAD4 R445* 4 0.06
ERBB3 D297Y 4 0.06
CTNNB1 T41I 4 0.06
TP53 K132E 4 0.06
PIK3CA V344G 4 0.06
TP53 R280G 4 0.06
PIK3R1 N564D 4 0.06
KRAS K117N 4 0.06
TP53 S215I 4 0.06
MAX H28R 4 0.06
STK11 SpliceDonorSNV 4 0.06
TP53 G244S 4 0.06
ERBB2 L755S 4 0.06
ERBB3 V104L 4 0.06
TP53 N239*fs 4 0.06
CIC R215W 4 0.06
MLL3 SpliceDonorSNV 4 0.06
CNOT3 E20K 4 0.06
RRAS2 Q72L 4 0.06
CDKN2A P48L 4 0.06
PIK3CA V344M 4 0.06
TP53 G262V 4 0.06
TP53 C135Y 4 0.06
TP53 K132R 4 0.06
APC T1556Nfs 4 0.06
APC R302* 4 0.06
APC S1346* 4 0.06
SMARCA4 R1135W 4 0.06
TP53 R196P 4 0.06
TP53 R249W 4 0.06
PIK3CA D350G 4 0.06
HRAS G13V 4 0.06
SOX17 S403I 4 0.06
CDKN2A Q50* 4 0.06
TP53 R273P 4 0.06
PPP6C S307L 4 0.06
APC R1114* 4 0.06
TSC2 SpliceAcceptorSNV 4 0.06
CHD4 R1162W 4 0.06
STIP1 SpliceAcceptorSNV 4 0.06
CLASP2 M965Wfs 4 0.06
TP53 S183* 4 0.06
NF1 R440* 4 0.06
HERC2 SpliceAcceptorSNV 4 0.06
KRAS Q61K 4 0.06
TP53 H179L 4 0.06
ERBB4 R711C 4 0.06
APC Q1378* 4 0.06
ARID1A R2158* 4 0.06
TP53 E56* 4 0.06
EGFR R108K 4 0.06
RHEB Y35N 4 0.06
TP53 P278A 4 0.06
SMARCA4 T910M 4 0.06
BRAF N581S 4 0.06
TP53 R175G 4 0.06
NCOR1 SpliceDonorSNV 4 0.06
CUL1 E485K 4 0.06
APC F1491Lfs 4 0.06
RB1 R579* 4 0.06
PTPN11 T468M 4 0.06
APC E1374* 4 0.06
FRG1 E176* 4 0.06
Showing only mutations observed in at least 4 samples. Use download if you want all of them.