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ZEB2 has not been detected as a mutational cancer driver

ZEB2
Ensembl id ENSG00000169554
Mutated samples
Coding Sequence 139 (2.0%)
Protein Affecting 110 (1.6%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ZEB2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung adenocarcinoma No 21 15 3.84
Lung squamous cell carcinoma No 17 15 8.62
Cutaneous melanoma No 15 13 3.52
Stomach adenocarcinoma No 11 9 5.59
Head and neck squamous cell carcinoma No 11 9 2.40
Uterine corpus endometrioid carcinoma No 8 8 3.48
Colorectal adenocarcinoma No 8 8 3.49
Breast carcinoma No 8 6 0.52
Small cell lung carcinoma No 7 5 7.25
Renal clear cell carcinoma No 4 4 0.96
Serous ovarian adenocarcinoma No 5 4 1.27
Hepatocarcinoma No 4 3 3.33
Esophageal carcinoma No 5 3 2.05
Bladder carcinoma No 4 2 2.04
Neuroblastoma No 2 2 0.95
Prostate adenocarcinoma No 2 1 0.41
Pancreas adenocarcinoma No 1 1 0.47
Non small cell lung carcinoma No 3 1 3.23
Lower grade glioma No 2 1 0.59
Medulloblastoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence