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XIRP2 has not been detected as a mutational cancer driver

XIRP2
Ensembl id ENSG00000163092
Mutated samples
Coding Sequence 484 (7.1%)
Protein Affecting 381 (5.6%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all XIRP2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 138 104 28.18
Lung adenocarcinoma No 72 65 16.62
Lung squamous cell carcinoma No 42 30 17.24
Stomach adenocarcinoma No 36 29 18.01
Head and neck squamous cell carcinoma No 37 29 7.73
Breast carcinoma No 28 22 1.92
Esophageal carcinoma No 16 14 9.59
Uterine corpus endometrioid carcinoma No 16 12 5.22
Renal clear cell carcinoma No 11 10 2.40
Bladder carcinoma No 11 9 9.18
Small cell lung carcinoma No 10 9 13.04
Hepatocarcinoma No 10 8 8.89
Glioblastoma multiforme No 10 8 2.11
Serous ovarian adenocarcinoma No 8 7 2.22
Non small cell lung carcinoma No 4 4 12.90
Chronic lymphocytic leukemia No 9 4 1.38
Prostate adenocarcinoma No 4 3 1.23
Pancreas adenocarcinoma No 5 3 1.40
Neuroblastoma No 4 3 1.43
Colorectal adenocarcinoma No 5 3 1.31
Acute myeloid leukemia No 1 1 0.51
Medulloblastoma No 1 1 0.48
Lower grade glioma No 1 1 0.59
Diffuse B cell lymphoma No 1 1 4.35
Acute lymphocytic leukemia No 1 1 0.82
Thyroid carcinoma No 1 0 0.00
Pylocytic astrocytoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence