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UGT1A5 has not been detected as a mutational cancer driver

UGT1A5
Ensembl id ENSG00000240224
Mutated samples
Coding Sequence 168 (2.5%)
Protein Affecting 35 (0.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all UGT1A5 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 70 14 3.79
Lung adenocarcinoma No 13 3 0.77
Lung squamous cell carcinoma No 9 3 1.72
Bladder carcinoma No 7 2 2.04
Breast carcinoma No 14 2 0.17
Uterine corpus endometrioid carcinoma No 6 2 0.87
Lower grade glioma No 5 2 1.18
Head and neck squamous cell carcinoma No 7 2 0.53
Non small cell lung carcinoma No 1 1 3.23
Serous ovarian adenocarcinoma No 3 1 0.32
Stomach adenocarcinoma No 8 1 0.62
Colorectal adenocarcinoma No 3 1 0.44
Esophageal carcinoma No 5 1 0.68
Hepatocarcinoma No 3 0 0.00
Medulloblastoma No 1 0 0.00
Renal clear cell carcinoma No 2 0 0.00
Thyroid carcinoma No 1 0 0.00
Neuroblastoma No 1 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
Glioblastoma multiforme No 7 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence