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UGT1A1 has not been detected as a mutational cancer driver

UGT1A1
Ensembl id ENSG00000241635
Mutated samples
Coding Sequence 64 (0.9%)
Protein Affecting 39 (0.6%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all UGT1A1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 29 17 4.61
Lung adenocarcinoma No 4 3 0.77
Lung squamous cell carcinoma No 3 3 1.72
Uterine corpus endometrioid carcinoma No 4 3 1.30
Bladder carcinoma No 2 2 2.04
Breast carcinoma No 5 2 0.17
Head and neck squamous cell carcinoma No 3 2 0.53
Glioblastoma multiforme No 4 2 0.53
Thyroid carcinoma No 1 1 0.31
Non small cell lung carcinoma No 1 1 3.23
Lower grade glioma No 1 1 0.59
Stomach adenocarcinoma No 2 1 0.62
Colorectal adenocarcinoma No 1 1 0.44
Medulloblastoma No 1 0 0.00
Esophageal carcinoma No 3 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence