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TPO has not been detected as a mutational cancer driver

TPO
Ensembl id ENSG00000115705
Mutated samples
Coding Sequence 196 (2.9%)
Protein Affecting 140 (2.1%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TPO gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 56 41 11.11
Lung adenocarcinoma No 20 15 3.84
Stomach adenocarcinoma No 18 13 8.07
Lung squamous cell carcinoma No 10 9 5.17
Head and neck squamous cell carcinoma No 11 8 2.13
Esophageal carcinoma No 13 8 5.48
Colorectal adenocarcinoma No 7 7 3.06
Bladder carcinoma No 7 6 6.12
Uterine corpus endometrioid carcinoma No 7 6 2.61
Pancreas adenocarcinoma No 6 4 1.87
Serous ovarian adenocarcinoma No 5 4 1.27
Glioblastoma multiforme No 5 4 1.06
Hepatocarcinoma No 7 3 3.33
Breast carcinoma No 5 3 0.26
Renal clear cell carcinoma No 5 3 0.72
Lower grade glioma No 2 2 1.18
Prostate adenocarcinoma No 1 1 0.41
Acute myeloid leukemia No 1 1 0.51
Neuroblastoma No 1 1 0.48
Pylocytic astrocytoma No 1 1 0.99
Non small cell lung carcinoma No 2 0 0.00
Chronic lymphocytic leukemia No 6 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence