IntOGen - TNFAIP3 gene cancer mutations

TNFAIP3 is detected as a mutational cancer driver

TNFAIP3 reports

Methods
Mutation distribution

Gene details

TNFAIP3
Ensembl ID ENSG00000118503 Transcript ID ENST00000612899 Protein ID ENSP00000481570
Cancer types where is driver 2 Cohorts where is driver 4 Mutated samples 14 Mutations 322
Mode of action Loss of function
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence